Patents by Inventor Heemin Kang

Heemin Kang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12297456
    Abstract: Disclosed are a nanobarcode for controlling adhesion and differentiation of stem cells and a method of controlling adhesion and differentiation of stem cells by using nanobarcodes. The method of controlling adhesion and differentiation of stem cells of the present invention may efficiently control adhesion and differentiation of stem cells in vivo or in vitro by tuning periodicity and sequences of a ligand peptide (RGD) of a nanobarcode.
    Type: Grant
    Filed: May 18, 2023
    Date of Patent: May 13, 2025
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Heemin Kang, Young Keun Kim, Sunhong Min, Yoo Sang Jeon, Hyojun Choi
  • Patent number: 12180505
    Abstract: Disclosed are a nanobarcode for controlling adhesion and differentiation of stem cells and a method of controlling adhesion and differentiation of stem cells by using nanobarcodes. The method of controlling adhesion and differentiation of stem cells of the present invention may efficiently control adhesion and differentiation of stem cells in vivo or in vitro by tuning periodicity and sequences of a ligand peptide (RGD) of a nanobarcode.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: December 31, 2024
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Heemin Kang, Young Keun Kim, Sunhong Min, Yoo Sang Jeon, Hyojun Choi
  • Patent number: 12161762
    Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
    Type: Grant
    Filed: May 30, 2023
    Date of Patent: December 10, 2024
    Assignee: Korea University Research and Business Foundation
    Inventors: Young-Keun Kim, Heemin Kang, Min-Jun Ko, Gunhyu Bae
  • Publication number: 20240387081
    Abstract: Disclosed is a magnetic structure having a spike structure, the magnetic structure comprising: a core including at least one magnetic nanoparticle; a buffer disposed on an outer surface of the core; a shell disposed on an outer surface of the buffer, and at least one spike structure protruding outwardly from the shell, wherein the spike structure is controlled to have various shapes.
    Type: Application
    Filed: January 8, 2024
    Publication date: November 21, 2024
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Sunhong Min, Hyunshik Hong, Seong Yeol Kim, Kanghyeon Kim, Chowon Kim
  • Patent number: 12138352
    Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: November 12, 2024
    Assignee: Korea University Research and Business Foundation
    Inventors: Young-Keun Kim, Heemin Kang, Min-Jun Ko, Gunhyu Bae
  • Publication number: 20240277846
    Abstract: A magnetic biomolecule-metal ion self-assembly complex for treatment includes an iron ion; and at least one ligand, wherein the ligand and the iron ion are reversibly self-assembled with each other or self-disassembled from each other, wherein the ligand and the iron ion are self-assembled with each other via a first bond to form a self-assembly, wherein the self-assembling is performed by at least one of the metal ion and the ligand, wherein the self-assembly includes a plural of self-assemblies, wherein the self-assemblies adjacent to each other self-bind to each other via a second bond to form the self-assembly complex. The magnetic biomolecule-metal ion self-assembly complex is effectively used for cancer treatment, osteoarthritis treatment, and bone defect treatment.
    Type: Application
    Filed: January 10, 2024
    Publication date: August 22, 2024
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Heemin KANG, Woo-Young JANG
  • Publication number: 20240199669
    Abstract: The present disclosure relates to a self-assembled complex composed of substances existing in a body and using the same as ligands, the self-assembled complex including: metal ions including one or more of cobalt (Co), silver (Ag), gadolinium (Gd), or iron (Fe); and one or more ligands that are self-assembled with the metal ions, wherein: the self-assembled complex is reversibly self-assembled or self-disassembled; self-assembly is performed by one or more of a concentration of the metal ions or a concentration of the ligand; and the form of the self-assembled complex is controlled depending on a combination of the ligands.
    Type: Application
    Filed: December 13, 2023
    Publication date: June 20, 2024
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Sungkyu LEE, Seong Yeol KIM, Yuri KIM
  • Patent number: 11981751
    Abstract: Disclosed are a nanobarcode for controlling adhesion and polarization of macrophages and a method of controlling adhesion and polarization of macrophages by using nanobarcodes. The method of controlling adhesion and polarization of macrophages of the present invention may efficiently control adhesion and phenotypic polarization of macrophages in vivo or in vitro by tuning periodicity and sequences of ligand peptide (RGD) of a nanobarcode.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: May 14, 2024
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Heemin Kang, Young Keun Kim, Sunhong Min, Yoo Sang Jeon, Hyojun Choi
  • Publication number: 20230330261
    Abstract: Disclosed is a self-assembled complex containing copper ions, including: copper ions; and one or more ligands, in which the ligands and the copper ions are reversibly self-assembled or self-degraded, and when there are a plurality of types of ligands or a plurality of ligands, the shape of the self-assembled complex is formed differently depending on the blending ratio of the ligands.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Sung-Gue LEE, Na-Yeon KANG, Yu-Ri KIM, Hyun-Shik HONG, Sang-Hyeok LEE, Cho-Won KIM, Seong-Yeol KIM
  • Publication number: 20230330232
    Abstract: Disclosed is a self-assembled complex containing an iron ion that includes an iron ion; and at least one ligand, where the iron ion and the ligand are reversibly self-assembled or self-disassembled. The iron ion and the ligand are self-assembled to form an assembly structure at least part of which is round shaped.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Yu-Ri KIM, Gun-Hyu BAE, Sung-Gue LEE, Na-Yeon KANG, Sun-Hong MIN, Seong-Yeol KIM
  • Publication number: 20230330005
    Abstract: Disclosed is a self-assembled complex containing a calcium ion that includes a calcium ion; and at least one ligand, where the calcium ion and the ligand participate in a reversibly self-assembly or self-disassembly. The shape of the self-assembled complex varies depending on the type of the ligand, or the mixing ratio of the ligand when there are a plurality of ligands.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin KANG, Sung-Gue LEE, Na-Yeon KANG, Yu-Ri KIM, Gun-Hyu BAE, Da-Hee KIM, Seong-Yeol KIM
  • Publication number: 20230301928
    Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
    Type: Application
    Filed: May 30, 2023
    Publication date: September 28, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Young-Keun KIM, Heemin KANG, Min-Jun KO, Gunhyu BAE
  • Publication number: 20230287351
    Abstract: Disclosed are a nanobarcode for controlling adhesion and differentiation of stem cells and a method of controlling adhesion and differentiation of stem cells by using nanobarcodes. The method of controlling adhesion and differentiation of stem cells of the present invention may efficiently control adhesion and differentiation of stem cells in vivo or in vitro by tuning periodicity and sequences of a ligand peptide (RGD) of a nanobarcode.
    Type: Application
    Filed: May 18, 2023
    Publication date: September 14, 2023
    Inventors: Heemin KANG, Young Keun KIM, Sunhong MIN, Yoo Sang JEON, Hyojun CHOI
  • Publication number: 20230241214
    Abstract: Discloses is a technology of collecting a biological sample, delivering a substance into a living body, and regulating macrophage adhesion and polarization, by controlling a self-assembled complex and a nanosystem including the same by irradiation with light.
    Type: Application
    Filed: May 27, 2022
    Publication date: August 3, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Heemin Kang, Yuri Kim, Gun-Hyu Bae, Sung-Gue Lee, Na-Yeon Kang
  • Publication number: 20230210992
    Abstract: The present invention relates to a nanosatellite-substrate complex capable of regulating stem cell adhesion and differentiation, and a method for preparing the same. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation by applying a magnetic field to the nanosatellite-substrate complex.
    Type: Application
    Filed: June 9, 2022
    Publication date: July 6, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Young-Keun KIM, Heemin KANG, THOMAS MYEONGSEOK KOO, Myeong-Soo KIM, Sung-Gue LEE, Gun-Hyu BAE
  • Publication number: 20230210996
    Abstract: According to the present invention, it is possible to provide a nanosatellite-substrate complex capable of regulating macrophage adhesion and polarization. In addition, according to the present invention, it is possible to provide a method for preparing a nanosatellite-substrate complex capable of regulating macrophage adhesion and polarization. In addition, according to the present invention, it is possible to provide a method of regulating macrophage adhesion and polarization using the nanosatellite-substrate complex.
    Type: Application
    Filed: June 7, 2022
    Publication date: July 6, 2023
    Applicant: Korea University Research and Business Foundation
    Inventors: Young-Keun KIM, Heemin KANG, THOMAS MYEONGSEOK KOO, Myeong-Soo KIM, Yuri KIM
  • Publication number: 20230152307
    Abstract: The present invention relates to a nanoscreen for regulating stem cell adhesion and differentiation. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation using the nanoscreen. According to the nanoscreen of the present invention and the method of regulating stem cell adhesion and differentiation using the same, it is possible to efficiently regulate stem cell adhesion and differentiation by applying a magnetic field to the nanoscreen.
    Type: Application
    Filed: October 11, 2022
    Publication date: May 18, 2023
    Applicants: Korea University Research and Business Foundation, Industry-University Cooperation Foundation Hanyang University ERICA Campus
    Inventors: Heemin KANG, Do-Kyoon KIM, Hyun-Shik HONG, Sun-Hong MIN
  • Publication number: 20230149605
    Abstract: The present invention relates to a nanobarrier for regulating macrophage adhesion and polarization. Moreover, the present invention relates to a method of regulating macrophage adhesion and polarization using the nanobarrier. According to the nanobarrier of the present invention and the method of regulating macrophage adhesion and polarization using the same, it is possible to efficiently regulate macrophage adhesion and polarization by applying a magnetic field to the nanobarrier.
    Type: Application
    Filed: October 11, 2022
    Publication date: May 18, 2023
    Applicants: Korea University Research and Business Foundation, Industry-University Cooperation Foundation Hanyang University ERICA Campus
    Inventors: Heemin KANG, Do-Kyoon KIM, Yu-Ri KIM, Gun-Hyu BAE
  • Publication number: 20220111059
    Abstract: The present invention relates to an effective component delivery system using self-assembly and self-disassembly of a self-assembled complex, and the effective component delivery system uses a self-assembled complex which is composed of substances existing in the body, thereby being less toxic and harmless to the human body, and the effective component delivery system is capable of controlling a self-disassembly rate and an effective component release rate by using various kinds of metal ions and ligands including phosphate or phosphonate.
    Type: Application
    Filed: April 19, 2021
    Publication date: April 14, 2022
    Applicant: Korea University Research and Business Foundation
    Inventors: HeeMin KANG, Gun Hyu BAE, Ramar THANGAM
  • Publication number: 20220110880
    Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.
    Type: Application
    Filed: July 7, 2021
    Publication date: April 14, 2022
    Applicant: Korea University Research and Business Foundation
    Inventors: Young-Keun KIM, Heemin KANG, Min-Jun KO, Gunhyu BAE