Patents by Inventor Hee Sook BAE

Hee Sook BAE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hemophilia B rat model
    Patent number: 12642256
    Abstract: The present invention relates to a hemophilia B rat and a method of producing the hemophilia B rat. More particularly, the present invention relates to a hemophilia B rat having F9 factor knocked-down or knocked-out and a method of producing the hemophilia B rat.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: June 2, 2026
    Assignee: TOOLGEN INCORPORATED
    Inventors: Jae Young Lee, Hee Sook Bae, Hye Jung Shin, Dong Woo Song, Un Gi Kim, Kyu Jun Lee
  • Artificial genome manipulation for gene expression regulation
    Patent number: 12163149
    Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: December 10, 2024
    Assignee: TOOLGEN INCORPORATED
    Inventors: Seokjoong Kim, Dong Woo Song, Jae Young Lee, Jung Min Lee, Gyu-bon Cho, Hee Sook Bae
  • VECTOR FOR DELIVERING ACTIVE AGENT TO NERVOUS SYSTEM, AND USE THEREOF
    Publication number: 20240216539
    Abstract: The present application relates to a vector for delivering an active agent to the nervous system. In one embodiment of the present application, a vector for delivering an active agent in which one or more TTR ligands are conjugated to the surface of an adeno-associated virus is provided.
    Type: Application
    Filed: February 28, 2024
    Publication date: July 4, 2024
    Inventors: Jae Young Lee, Sang Woo Ham, Hee Sook Bae, Gyu Bon Cho, Jae Hyung Jang, Yun Ha Kim, Dong Soo Lee
  • ARTIFICIAL GENOME MANIPULATION FOR GENE EXPRESSION REGULATION
    Publication number: 20230295652
    Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
    Type: Application
    Filed: December 28, 2022
    Publication date: September 21, 2023
    Inventors: Seokjoong KIM, Dong Woo SONG, Jae Young LEE, Jung Min LEE, Gyu-bon CHO, Hee Sook BAE
  • Artificial genome manipulation for gene expression regulation
    Patent number: 11572574
    Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: February 7, 2023
    Assignee: TOOLGEN INCORPORATED
    Inventors: Seokjoong Kim, Dong Woo Song, Jae Young Lee, Jung Min Lee, Gyu-bon Cho, Hee Sook Bae
  • HEMOPHILIA B RAT MODEL
    Publication number: 20220192163
    Abstract: The present invention relates to a hemophilia B rat and a method of producing the hemophilia B rat. More particularly, the present invention relates to a hemophilia B rat having F9 factor knocked-down or knocked-out and a method of producing the hemophilia B rat.
    Type: Application
    Filed: March 24, 2020
    Publication date: June 23, 2022
    Inventors: Jae Young LEE, Hee Sook BAE, Hye Jung SHIN, Dong Woo SONG, Un Gi KIM, Kyu Jun LEE
  • ARTIFICIAL GENOME MANIPULATION FOR GENE EXPRESSION REGULATION
    Publication number: 20200199617
    Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 25, 2020
    Inventors: Seokjoong KIM, Dong Woo SONG, Jae Young LEE, Jung Min LEE, Gyu-bon CHO, Hee Sook BAE
  • Genome Editing System For Repeat Expansion Mutation
    Publication number: 20200101173
    Abstract: The present specification relates to an artificial manipulation or modification in an expression regulatory gene of an over-amplified repeated sequence. More specifically, a system for regulating the expression of an over-amplified repeated sequence including an artificially manipulated gene to reduce the expression of the over-amplified repeated sequence. The artificially manipulated gene includes one or more genes selected from the group consisting of an SPT4 gene, SPT5 gene, SUPT4H gene, and SUPT5H gene. The artificially manipulated gene includes an artificial mutation in a genomic sequence of the gene. The artificially manipulated gene includes a gene whose function is impaired or has reduced expression.
    Type: Application
    Filed: June 14, 2018
    Publication date: April 2, 2020
    Inventors: Jae Young LEE, Seokjoong KIM, Hee Sook BAE, Jihwan SONG, Hyun Jung PARK