Abstract: The present invention relates to a novel use of an ?1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in ?1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The ?1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract: A micro manipulator for electrode movement, a driving method thereof, and a brain signal measuring device using the same are provided.

Abstract: The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1G protein of T-type calcium channels, use of suppressor of alpha 1G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1G subunit of T-type calcium channel, and preparation method thereof. The ?1G-knockout transgenic mouse can be used for investigating the relationship between diseases particularly neuropathy or psychopathy and the function of ?1G T-type calcium channel via various behavioral tests since ?1G subunit is mainly expression in central nervous system (CNS) and pheripheral nervous system (PNS). Further, the ?1G-knockout transgenic mouse can be used for screening antileptic agents.

Abstract: The present invention relates to a novel use of an ?1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in ?1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The ?1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract: A micro manipulator for electrode movement, a driving method thereof, and a brain signal measuring device using the same are provided.

Abstract: A polymer linear actuator for a micro electro mechanical system (MEMS) and a micro manipulator for a measurement device of cranial nerve signal using the same are provided. The polymer linear actuator has first and second bodies positioned spaced apart to a distance from each other, and one or more pairs of V-type moving units connecting the first and second bodies together, wherein the moving units in pair are opposed to each other to convert a rotation motion of the respective moving units into a linear motion, thereby causing the first and second bodies to move linearly.

Abstract: The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type ?1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type ?1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type ?1H calcium channels.

Abstract: The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1 G protein of T-type calcium channels, use of suppressor of alpha 1 G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1 G subunit of T-type calcium channel, and preparation method thereof. In addition, suppressing alpha 1 G protein of T-type calcium channels does not occur epilepsy, and alpha 1 G-deficient mice are useful to study of mechanism related to epilepsy.

Abstract: The present invention relates to the method for decreasing depression, more particularly to the method for decreasing depression by inhibiting the activity of N-type calcium channel. According to the present invention, inhibiting material of N-type calcium channel activity can effectively be used for the depression remedy. Also, anti-depression reagent can be screened using N-type calcium channel.

Abstract: The present invention relates to a novel use of an ?1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in ?1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The ?1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Abstract: The disclosure concerns a method for the suppression of visceral pain by regulating the T-type calcium channel; a visceral pain inhibitor that includes a T-type calcium channel inhibitor as an effective ingredient; and a method of screening a visceral pain inhibitor by investigating the suppression activity of T-type calcium channels. Particularly, the present invention relates to a method for the suppression of visceral pain by regulating an alpha 1G T-type calcium channel in the central nervous system and alpha 1H and alpha 1I T-type calcium channels in the peripheral nervous system; a visceral pain inhibitor that includes a T-type calcium channel inhibitor as an effective ingredient; and a method of screening a visceral pain inhibitor by investigating the suppression activity of T-type calcium channels. The method of the present invention can be effectively used to suppress visceral pain by regulating T-type calcium channel in a precise mechanism without any side effects.

Abstract: A new Bcl-2 related gene "Bfl-1", a polypeptide encoded by said gene, and a plasmid and a transformant comprising said gene are disclosed. The gene can be used to detect cancer.