Abstract: Techniques are described for delivering a metered flow of tritium gas to a fusion power system at a constant (or substantially constant) flow without feedback control being necessary, and while allowing all (or almost all) of the tritium in a reservoir to be delivered to the system. A constant pressure (isobaric) tritium injection system is described comprising a process chamber, at least part of which is flexible, and a regulating chamber arranged adjacent to the process chamber. Tritium in the process chamber may be pushed out of the injection system by managing the pressure of a regulating gas in the regulating chamber. As the pressure of the regulating gas increases, this causes the process chamber to be compressed due to the flexible portion(s) of the process chamber, thereby increasing the pressure of the tritium gas.

Abstract: A system for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous-flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to one another to perform various unit operations in the cell bioprocessing or cell-therapy manufacturing chain to enable direct processing of a blood or blood product sample. The system can automatically and continuously process the sample into genetically-modified lymphocytes or T cells for cellular therapy. The technologies implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoretic media exchange or cell washing, and continuous-flow microfluidic electrotransfection. Modules implementing these microfluidic technologies can be interconnected with plastic tubing or with a custom manifold.

Abstract: The present disclosure describes a systems and methods to rapidly detect a level of a drug present in a fluid sample. The systems and methods can be used to monitor drug levels in the blood of a patient to whom the drug has been prescribed. A system can include one or more organic electrochemical transistors that are functionalized with a coating that may include aptamers or antibodies. The coating can bind or otherwise interact with the drug of interest to change the transconductance of the organic electrochemical transistors. The system can detect a change in the transconductance of the organic electrochemical transistors and signal the presence of the drug.