Patents by Inventor Heesun RYU

Heesun RYU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolopyridine derivative and use thereof in prevention and treatment of protein kinase-related disease
    Patent number: 12240844
    Abstract: [Summary] The present invention relates to a pyrrolopyridine derivative and a pharmaceutical composition comprising the same as an active ingredient for prevention or treatment of a protein kinase-related disease. The pyrrolopyridine derivative has excellent inhibitory activity against various protein kinases including LRRK2, DYRK1, and CLK1 and exhibits an excellent suppressive effect on the growth of triple-negative breast cancer cells. A pharmaceutical composition comprising the same as an active ingredient can be advantageously used for treating or preventing protein kinase-related diseases, inter alia, cancers, degenerative brain diseases, and inflammatory diseases, and specifically for treating triple-negative breast cancer.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: March 4, 2025
    Assignee: Voronoi, Inc.
    Inventors: Myungho Jung, Jungyeon Yun, Dahoon Ma, Sohyun Chung, Hyeonho Jeon, Heesun Ryu, Hyunkyung Kim, Hwan Kim, Jungbeom Son, Namdoo Kim, Jieun Choi, Daekwon Kim
  • PYRROLOPYRIMIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT
    Publication number: 20230066011
    Abstract: The present invention relates to a pyrrolopyrimidine derivative, and a pharmaceutical composition for preventing or treating protein kinase-related disease comprising the same as an active ingredient. The pyrrolopyrimidine derivative has excellent inhibitory activity against various protein kinases comprising LRRK2, and has an excellent effect of inhibiting the proliferation of triple-negative breast cancer cells. Therefore, the pharmaceutical composition comprising the pyrrolopyrimidine derivative as an active ingredient may be useful for the treatment or prevention of protein kinase-related diseases, in particular, cancer, degenerative brain diseases, and inflammatory diseases, and specifically, may be useful for the treatment of triple-negative breast cancer.
    Type: Application
    Filed: January 20, 2020
    Publication date: March 2, 2023
    Inventors: Myungho JUNG, Jungyeon YUN, Dahoon MA, Sohyun CHUNG, Hyeonho JEON, Heesun RYU, Hyunkyung KIM, Hwan KIM, Jungbeom SON, Namdoo KIM, Jieun CHOI, Daekwon KIM
  • PYRROLOPYRIDINE DERIVATIVE AND USE THEREOF IN PREVENTION AND TREATMENT OF PROTEIN KINASE-RELATED DISEASE
    Publication number: 20220064161
    Abstract: The present invention relates to a pyrrolopyridine derivative and a pharmaceutical composition comprising the same as an active ingredient for prevention or treatment of a protein kinase-related disease. The pyrrolopyridine derivative has excellent inhibitory activity against various protein kinases including LRRK2, DYRK1, and CLK1 and exhibits an excellent suppressive effect on the growth of triple-negative breast cancer cells. A pharmaceutical composition comprising the same as an active ingredient can be advantageously used for treating or preventing protein kinase-related diseases, inter alia, cancers, degenerative brain diseases, and inflammatory diseases, and specifically for treating triple-negative breast cancer.
    Type: Application
    Filed: January 20, 2020
    Publication date: March 3, 2022
    Inventors: Myungho JUNG, Jungyeon YUN, Dahoon MA, Sohyun CHUNG, Hyeonho JEON, Heesun RYU, Hyunkyung KIM, Hwan KIM, Jungbeom SON, Namdoo KIM, Jieun CHOI, Daekwon KIM