Patents by Inventor Heide L. Ford

Heide L. Ford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF EYA2
    Publication number: 20140155420
    Abstract: The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.
    Type: Application
    Filed: January 10, 2012
    Publication date: June 5, 2014
    Applicants: The Regents of the University of Colorado, a body corporate, Department of Health and Human Services
    Inventors: Rui Zhao, Heide L. Ford, Noel Southall, Erika Englund, Samarjit Patnaik, Marc Ferrer, Wei Zheng, Seameen Dehdashti, Juan Marugan
  • Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions
    Patent number: 8076304
    Abstract: The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: December 13, 2011
    Assignee: The Regents of the University of Colorado
    Inventors: Heide L. Ford, Ricardo D. Coletta, Arthur R. Pardee, Justin Lamb
  • Methods and Compositions for the Diagnosis and Treatment of Cyclin A-1 Associated Conditions
    Publication number: 20110223171
    Abstract: The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 15, 2011
    Inventors: Heide L. Ford, Ricardo D. Coletta, Arthur R. Pardee, Justin Lamb
  • METHODS FOR INHIBITING SIX1 AND EYA PROTEINS
    Publication number: 20110038791
    Abstract: In some aspects, the invention provides a method of inhibiting interaction of Six1 with Eya2 comprising contacting a cell expressing Six1 and Eya2 with an agent that inhibits binding of Six1 to Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Six1. In other apsects, the invention provides a method of treating cancer in a subject comprising administering to said subject an effective amount of an agent that inhibits Six1 interaction with Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Six1. In some embodiments, the invention further provides for the administration of a second cancer therapy to the patient. In still further aspects, the invention provides a method of identifying a candidate anti-cancer agent. The candidate inhibitor may be a nucleic acid, a protein, a peptide or a small molecule.
    Type: Application
    Filed: February 25, 2009
    Publication date: February 17, 2011
    Inventors: Heide L. Ford, Rui Zhao, Aaron Patrick
  • Methods and compositions for diagnosing and predicting the behavior of cancer
    Patent number: 7153700
    Abstract: The present invention relates to methods for detecting the presence of SIX1 protein or nucleic acid in a biological sample in which a biological sample is contacted with an agent capable of detecting SIX1 protein or mRNA such that the presence of SIX1 is detected in the biological sample. Diagnostic and prognostic methods utilizing HSIX1 as an indicator of cancer and cancer progression are also provided. Compositions and kits for detecting the presence of SIX1 in a biological sample are also described.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: December 26, 2006
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Arthur B. Pardee, Heide L. Ford