Patents by Inventor Heidi L. Perez

Heidi L. Perez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CXCR4 receptor antagonists
    Patent number: 10450318
    Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: October 22, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gretchen M. Schroeder, Tram N. Huynh, Heidi L. Perez
  • CXCR4 RECEPTOR ANTAGONISTS
    Publication number: 20180327409
    Abstract: The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
    Type: Application
    Filed: December 14, 2016
    Publication date: November 15, 2018
    Inventors: Gretchen M. Schroeder, Tram N. Huynh, Heidi L. Perez
  • Tubulysin analogs and methods of making and use
    Patent number: 10077287
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: September 18, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Heidi L. Perez, Donna Wei, Robert M. Borzilleri, Sanjeev Gangwar, Gretchen M. Schroeder, Heng Cheng, Robert J. Schmidt
  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9902740
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 27, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • IAP antagonists
    Patent number: 9783573
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: October 10, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Kyoung S. Kim, Heidi L. Perez, Erik M. Stang, David K. Williams, Liping Zhang
  • MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
    Publication number: 20170260205
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Inventors: Yong ZHANG, Robert M. BORZILLERI, Andrew J. TEBBEN, Erik STANG, Andrew F. DONNELL, Gretchen M. SCHROEDER, Heidi L. PEREZ, Donna D. WEI
  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9688694
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 27, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
    Publication number: 20160376288
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: June 22, 2016
    Publication date: December 29, 2016
    Inventors: Yong ZHANG, Robert M. BORZILLERI, Andrew J. TEBBEN, Erik M. STANG, Andrew F. DONNELL, Gretchen M. SCHROEDER, Heidi L. PEREZ, Donna D. WEI
  • IAP antagonists
    Patent number: 9453048
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: September 27, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Donna D. Wei, Kyoung S. Kim
  • Substituted sulfonamides useful as antiapoptotic Bcl inhibitors
    Patent number: 9346795
    Abstract: Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: May 24, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Zhen-Wei Cai, Andrew J. Tebben, Heidi L. Perez, Liping Zhang, Gretchen M. Schroeder, Donna D. Wei
  • TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE
    Publication number: 20160130299
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: August 24, 2015
    Publication date: May 12, 2016
    Inventors: Heidi L. PEREZ, Donna WEI, Robert M. BORZILLERI, Sanjeev GANGWAR, Gretchen M. SCHROEDER, Heng CHENG, Robert J. SCHMIDT
  • IAP ANTAGONISTS
    Publication number: 20150322111
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Application
    Filed: September 17, 2013
    Publication date: November 12, 2015
    Inventors: Robert M. Borzilleri, Kyoung S. Kim, Heidi L. Perez, Erik M. Stang, David K. Williams, Liping Zhang
  • IAP ANTAGONISTS
    Publication number: 20150225452
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
    Type: Application
    Filed: August 6, 2013
    Publication date: August 13, 2015
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Donna D. Wei, Kyoung S. Kim
  • IAP antagonists
    Patent number: 8889712
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: November 18, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Erik M. Stang, Kyoung S. Kim
  • SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
    Publication number: 20140135318
    Abstract: Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: May 23, 2012
    Publication date: May 15, 2014
    Applicant: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Zhen-Wei Cai, Andrew J. Tebben, Heidi L. Perez, Liping Zhang, Gretchen M. Schroeder, Donna D. Wei
  • IAP ANTAGONISTS
    Publication number: 20130338081
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Application
    Filed: June 19, 2013
    Publication date: December 19, 2013
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Erik M. Stang, Kyoung S. Kim