Abstract: A system and process is provided for integrating and controlling devices within an environment for executing a procedure. A state of the environment is determined, at least in part, from the monitored information received from the device(s). In response to a predetermined workflow plan and in view of the determined state of the environment, commands are identified for one or more of the multiple devices to support execution of the workflow plan. A middleware bridge is provided for allowing any application to communicate with any device, given that capabilities of the device satisfy requirements of the application. The middleware system includes a device driver generator adapted for creating device drivers from static, descriptive files, and a service generator adapted for generating services from the device model and application requirements. Integration is accomplished by a matching of device and application services. The devices can be medical devices in a clinical environment.