Patents by Inventor Heike Herbert

Heike Herbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of insulin or an insulin derivative in the presence of oxygen
    Patent number: 7659363
    Abstract: The present invention comprises a process for preparing insulin or an insulin derivative with correctly linked cysteine bridges from a precursor of said insulin or insulin derivative, wherein said precursor is subjected to a folding process in the presence of cysteine or cysteine hydrochloride and a chaotropic auxiliary compound. The insulin or insulin derivative with correctly linked cysteine bridges is obtained by enzymic cleavage by means of trypsin or a trypsin-like enzyme and, where appropriate, additionally by means of carboxypeptidase B and subsequent purification on an adsorber resin, which process is carried out at varied pH and temperature ranges.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: February 9, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Franz-Josef Rubroeder, Reinhold Keller, Heike Herbert
  • METHOD FOR EXTRACTING INSULINS BY IMPROVED AIR-GASSING OF A FOLDING
    Publication number: 20070106063
    Abstract: The present invention comprises a process for preparing insulin or an insulin derivative with correctly linked cysteine bridges from a precursor of said insulin or insulin derivative, wherein said precursor is subjected to a folding process in the presence of cysteine or cysteine hydrochloride and a chaotropic auxiliary compound. The insulin or insulin derivative with correctly linked cysteine bridges is obtained by enzymic cleavage by means of trypsin or a trypsin-like enzyme and, where appropriate, additionally by means of carboxypeptidase B and subsequent purification on an adsorber resin, which process is carried out at varied pH and temperature ranges.
    Type: Application
    Filed: October 2, 2006
    Publication date: May 10, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Franz-Josef RUBROEDER, Reinhold KELLER, Heike HERBERT