Patents by Inventor Heike Schacke

Heike Schacke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
    Patent number: 11311520
    Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: April 26, 2022
    Assignees: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Ulrich Klar, Rolf Bohlmann, Heike Schäcke, Detlev Sülzle, Stephan Menz, Olaf Panknin
  • SUBSTITUTED DIHYDROIMIDAZOPYRIDINEDIONES AS MKNK1 AND MKNK2 INHIBITORS
    Publication number: 20210085656
    Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: August 3, 2020
    Publication date: March 25, 2021
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Ulrich KLAR, Rolf BOHLMANN, Heike SCHÄCKE, Detlev SÜLZLE, Stephan MENZ, Olaf PANKNIN
  • SUBSTITUTED IMIDAZOPYRIDINPYRIMIDINES
    Publication number: 20190388425
    Abstract: The present invention relates to substituted imidazopyridinpyrimidine compounds of general formula (I) which inhibit MKNK1 and MKNK2 kinase (also known as MAP Kinase interacting Kinase, Mnk1 and Mnk2), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 19, 2018
    Publication date: December 26, 2019
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Ulrich KLAR, Heike SCHÄCKE, Detlev SÜLZLE, Stephan MENZ
  • SUBSTITUTED DIHYDROIMIDAZOPYRIDINEDIONES AS MKNK1 AND MKNK2 INHIBITORS
    Publication number: 20190350910
    Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (A) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 15, 2018
    Publication date: November 21, 2019
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Ulrich KLAR, Rolf BOHLMANN, Heike SCHÄCKE, Detlev SÜLZLE, Stephan MENZ, Olaf PANKNIN
  • 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
    Patent number: 8680117
    Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: March 25, 2014
    Assignee: Bayer Schering Pharma AG
    Inventors: Markus Berger, Hartmut Rehwinkel, Thomas Zollner, Bkkehard May, Jorma Hassfeld, Heike Schacke
  • 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
    Patent number: 8394958
    Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: March 12, 2013
    Assignee: Bayer Pharma AG
    Inventors: Markus Berger, Hartmut Rehwinkel, Thomas Zollner, Ekkehard May, Jorma Hassfeld, Heike Schacke
  • 5-[(3,3,3-TRIFLUORO-2-HYDROXY-1-ARYLPROPYL)AMINO]-1H-QUINOLIN-2-ONES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20130005766
    Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 3, 2013
    Applicant: BAYER PHARMA AG
    Inventors: Markus BERGER, Hartmut REHWINKEL, Thomas ZOLLNER, Bkkehard MAY, Jorma HASSFELD, Heike SCHACKE
  • Benzyl Amines, A Process For Their Production And Their Use As Anti-Inflammtory Agents
    Publication number: 20120289510
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 15, 2012
    Applicants: AstraZeneca AB, Bayer Pharma AG
    Inventors: Markus Berger, Jan Dahmen, Hartmut Rehwinkel, Stefan Jaroch, Heike Schäcke
  • Benzyl, amines, a process for their production and their use as anti-inflammatory agents
    Patent number: 8173676
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: May 8, 2012
    Assignees: Bayer Pharma AG, AstraZeneca AB
    Inventors: Markus Berger, Jan Dahmen, Hartmut Rehwinkel, Stefan Jaroch, Heike Schäcke
  • BENZYL, AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20110301347
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: August 15, 2011
    Publication date: December 8, 2011
    Inventors: Markus BERGER, Jan Dahmen, Hartmut Rehwinkel, Stefan Jaroch, Heike Schäcke
  • Tetrahydronaphthalene derivatives, methods for the production thereof, and the use thereof as antiphlogistics
    Patent number: 7880042
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: February 1, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Markus Berger, Hartmut Rehwinkel, Heike Schäcke, Stefan Bäurle, Norbert Schmees
  • TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS
    Publication number: 20100298311
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
    Type: Application
    Filed: July 30, 2010
    Publication date: November 25, 2010
    Inventors: Markus BERGER, Hartmut REHWINKEL, Heike SCHÄCKE, Stefan BÄURLE, Norbert SCHMEES
  • 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents
    Publication number: 20100016338
    Abstract: The present invention relates to compounds of formula I, processes and intermediates for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: July 20, 2009
    Publication date: January 21, 2010
    Applicants: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, ASTRAZENECA AB
    Inventors: Markus Berger, Hartmut Rehwinkel, Ekkehard May, Heike Schäcke
  • 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents
    Publication number: 20090137564
    Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: November 21, 2008
    Publication date: May 28, 2009
    Inventors: Markus Berger, Hartmut Rehwinkel, Thomas Zollner, Ekkehard May, Jorna Hassfeld, Heike Schacke
  • TETRAHYDRONAPHTHALENYLAMIDES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20080200519
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Inventors: Markus BERGER, Hartmut Rehwinkel, Heike Schacke, Ekkehard May, Werner Skuballa, Hermann Kunzer
  • BENZYL AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20080032986
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: July 13, 2007
    Publication date: February 7, 2008
    Inventors: Markus Berger, Jan Dahmen, Hartmut Rehwinkel, Stefan Jaroch, Heike Schacke
  • Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents
    Publication number: 20070225290
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 27, 2007
    Inventors: Markus Berger, Hartmut Rehwinkel, Heike Schacke, Stefan Baurle, Norbert Schmees