Abstract: The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.

Abstract: A well tool includes a first component, a second component having a passage for receiving the first component, and an anchor assembly. The anchor assembly includes at least one anchor positioned on the first component that is received by at least one profile formed on an inner surface defining the passage of the second component. Either or both of the at least one profile and the at least one anchor include a ramp section that has a ramp contour defined by a ramp tangent. The ramp tangent forms an acute angle with a longitudinal axis of the borehole. A related method includes the steps of forming at least one profile in the second component, the at least one profile including a ramped section; disposing at least one anchor in the first component; and lowering the first component relative to the second component until the first anchor and the first profile align the first component and the second component in a predetermined relative alignment.

Abstract: Methods and systems for generating pulses in drilling fluid are described. The methods include driving rotation of a rotor relative to a stator of a pulser assembly in an oscillatory manner. The oscillatory manner includes rotating an obstructing element from a middle position to a first blocking angle position and rotating the obstructing element from the first blocking angle position to a second blocking angle position such that selective obstruction occurs. Rotation of the at least one obstructing element selectively obstructs a stator flow passage when drilling fluid is flowing through the drill string to generate a pressure pulse in the drilling fluid and the oscillatory manner is an oscillation of the obstructing element between the first blocking angle position and the second blocking angle position such that a single oscillation is between two obstructed states of the stator flow passage.

Abstract: An apparatus for drilling a directional wellbore is disclosed that in one non-limiting embodiment includes a drive for rotating a drill bit, a deflection device that enables a lower section of the drilling assembly to tilt about a member of the deflection device within a selected plane when the drilling assembly is substantially rotationally stationary to allow drilling of a curved section of the wellbore when the drill bit is rotated by the drive and wherein the tilt is reduced when the drilling assembly is rotated to allow drilling of a straighter section of the wellbore, and a tilt sensor that provides measurements relating to tilt of the lower section. A controller determines a parameter of interest relating to the tilt for controlling drilling of the directional wellbore.

Abstract: An apparatus for drilling a directional wellbore is disclosed that in one non-limiting embodiment includes a drive for rotating a drill bit, a deflection device that enables a lower section a drilling assembly to tilt within a selected plane when the drilling assembly is substantially rotationally stationary to allow drilling of a curved section of the wellbore when the drill bit is rotated by the drive and wherein the tilt is reduced when the drilling assembly is rotated to allow drilling of a straighter section of the wellbore, and a sensor that provides measurements relating a direction of the drilling assembly for drilling the wellbore along a desired direction.

Abstract: An apparatus for drilling directional wellbores is disclosed that in one non-limiting embodiment includes a drive for rotating a drill bit, a deflection device that enables a lower section of a drilling assembly to tilt about a member of the deflection device within a selected plane when the drilling assembly is substantially rotationally stationary to allow drilling of a curved section of the wellbore when the drill bit is rotated by the drive and wherein the tilt is reduced when the drilling assembly is rotated to allow drilling of a straighter section of the wellbore, and at least one seal that isolates at least a surface of the member from outside environment.

Abstract: A well tool includes a first component, a second component, an orientation assembly, and a coupling device. The first component has a first device and the second component has a passage for receiving the first component and a second device. The orientation assembly causes a predetermined relative orientation between the first and the second component. The coupling device operatively couples the first device with the second device upon the orientation assembly orienting the first component with the second component in the predetermined relative orientation. The coupling device also communicates at least one of power and information between the first and the second device.

Abstract: Methods and systems for generating pulses in drilling fluid are described. The methods include driving rotation of a rotor relative to a stator of a pulser assembly in an oscillatory manner. The oscillatory manner includes rotating an obstructing element from a middle position to a first blocking angle position and rotating the obstructing element from the first blocking angle position to a second blocking angle position such that selective obstruction occurs. Rotation of the at least one obstructing element selectively obstructs a stator flow passage when drilling fluid is flowing through the drill string to generate a pressure pulse in the drilling fluid and the oscillatory manner is an oscillation of the obstructing element between the first blocking angle position and the second blocking angle position such that a single oscillation is between two obstructed states of the stator flow passage.

Abstract: Extendable elements of downhole tools are provided having an extension direction component perpendicular to a tool axis, wherein a force is applied to the extendable element when in operation. The extendable elements comprise a first cross-section that includes the extension direction component, a first surface configured to receive a first force component of the force, the first force component substantially perpendicular to the first surface and a second surface configured to transfer at least a portion of the first force component of the force to a body of the downhole tool. The second surface and the extension direction component perpendicular to the tool axis draw a first angle that is between 0° and 90°.

Abstract: Systems and methods to perform a downhole operations in a borehole comprising moving, using surface equipment, an inner structure and an outer structure within the borehole, the outer structure equipped with an interaction device and the inner structure configured to be moved relative to the outer structure in a direction parallel to the borehole by the surface equipment, transmitting, by a transmitter, a downlink instruction to the inner structure, and performing an interaction routine with the interaction device in response to the downlink instruction, wherein the interaction routine comprises an interaction at least partially outside of the outer structure to perform the downhole operation.

Abstract: System and methods for engaging and disengaging running tools with a liner in a downhole system are described herein. The system and methods include a liner disposed in a borehole, the liner having at least one running tool engagement section, a running tool disposed within the liner, the running tool having at least one engagement module that is operable from a disengaged position to an engaged position and that is operable from an engaged position to a disengaged position, and an electronic device disposed at least one of in or on the engagement module.

Abstract: An apparatus for use in a wellbore is disclosed that in one non-limiting embodiment includes a flow restriction device that that contains a channeling element having a fluid flow passage, a restriction element spaced from the channeling element defining a gap between the restriction element and the channeling element, wherein relative movement between the restriction element and the channeling element obstructs flow of a fluid flowing through the flow passage to increase pressure in the fluid across the device. In one embodiment an activation device displaces one of the channeling element and the restriction element to adjusts or alter gap in response to certain changes in the pressure across the restriction device.

Abstract: Systems and methods to perform a downhole operations in a borehole comprising moving, using surface equipment, an inner structure and an outer structure within the borehole, the outer structure equipped with an interaction device and the inner structure configured to be moved relative to the outer structure in a direction parallel to the borehole by the surface equipment, transmitting, by a transmitter, a downlink instruction to the inner structure, and performing an interaction routine with the interaction device in response to the downlink instruction, wherein the interaction routine comprises an interaction at least partially outside of the outer structure to perform the downhole operation.

Abstract: A well tool includes a first component, a second component, an orientation assembly, and a coupling device. The first component has a first device and the second component has a passage for receiving the first component and a second device. The orientation assembly causes a predetermined relative orientation between the first and the second component. The coupling device operatively couples the first device with the second device upon the orientation assembly orienting the first component with the second component in the predetermined relative orientation. The coupling device also communicates at least one of power and information between the first and the second device.

Abstract: A well tool includes a first component, a second component having a passage for receiving the first component, and an anchor assembly. The anchor assembly includes at least one anchor positioned on the first component that is received by at least one profile formed on an inner surface defining the passage of the second component. Either or both of the at least one profile and the at least one anchor include a ramp section that has a ramp contour defined by a ramp tangent. The ramp tangent forms an acute angle with a longitudinal axis of the borehole. A related method includes the steps of forming at least one profile in the second component, the at least one profile including a ramped section; disposing at least one anchor in the first component; and lowering the first component relative to the second component until the first anchor and the first profile align the first component and the second component in a predetermined relative alignment.

Abstract: An apparatus for use in a wellbore is disclosed that in one non-limiting embodiment includes a flow restriction device that that contains a channeling element having a fluid flow passage, a restriction element spaced from the channeling element defining a gap between the restriction element and the channeling element, wherein relative movement between the restriction element and the channeling element obstructs flow of a fluid flowing through the flow passage to increase pressure in the fluid across the device. In one embodiment an activation device displaces one of the channeling element and the restriction element to adjusts or alter gap in response to certain changes in the pressure across the restriction device.

Abstract: System and methods for engaging and disengaging running tools with a liner in a downhole system are described herein. The system and methods include a liner disposed in a borehole, the liner having at least one running tool engagement section, a running tool disposed within the liner, the running tool having at least one engagement module that is operable from a disengaged position to an engaged position and that is operable from an engaged position to a disengaged position, and an electronic device disposed at least one of in or on the engagement module.

Abstract: Extendable elements of downhole tools are provided having an extension direction component perpendicular to a tool axis, wherein a force is applied to the extendable element when in operation. The extendable elements comprise a first cross-section that includes the extension direction component, a first surface configured to receive a first force component of the force, the first force component substantially perpendicular to the first surface and a second surface configured to transfer at least a portion of the first force component of the force to a body of the downhole tool. The second surface and the extension direction component perpendicular to the tool axis draw a first angle that is between 0° and 90°.

Abstract: An apparatus for drilling a directional wellbore is disclosed that in one non-limiting embodiment includes a drive for rotating a drill bit, a deflection device that enables a lower section a drilling assembly to tilt within a selected plane when the drilling assembly is substantially rotationally stationary to allow drilling of a curved section of the wellbore when the drill bit is rotated by the drive and wherein the tilt is reduced when the drilling assembly is rotated to allow drilling of a straighter section of the wellbore, and a sensor that provides measurements relating a direction of the drilling assembly for drilling the wellbore along a desired direction.

Abstract: An apparatus for drilling directional wellbores is disclosed that in one non-limiting embodiment includes a drive for rotating a drill bit, a deflection device that enables a lower section of a drilling assembly to tilt about a member of the deflection device within a selected plane when the drilling assembly is substantially rotationally stationary to allow drilling of a curved section of the wellbore when the drill bit is rotated by the drive and wherein the tilt is reduced when the drilling assembly is rotated to allow drilling of a straighter section of the wellbore, and at least one seal that isolates at least a surface of the member from outside environment.