Abstract: The disclosure relates to a method and a device for diagnosing an internal combustion engine of a powertrain. The powertrain includes the internal combustion engine and a transmission unit, and the diagnosis is carried out using a running irregularity signal, where potentially a gear change is actively requested. The method includes ascertaining a diagnostic value of the internal combustion engine during operation using the running irregularity signal of the internal combustion engine. The powertrain is operated using a diagnostic gear of the transmission unit. The method also includes detecting the diagnostic gear which is engaged in the transmission unit while ascertaining the diagnostic value; and comparing the ascertained diagnostic value with a predefined diagnostic threshold value and comparing the diagnostic gear of the transmission unit with at least one predefined gear of the transmission unit.