Patents by Inventor Heiko Mielke

Heiko Mielke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of antisense oligonucleotides for the treatment of degenerative skin conditions
    Publication number: 20060025363
    Abstract: A pharmaceutical or cosmetic composition for topical application containing one or more oligonucleotides which are capable of hybridizing with a mRNA or a gene sequence which codes for a connective-tissue decomposing enzyme, or a physiologically compatible salt thereof. The compositions are suitable in particular for the treatment of degenerative skin conditions.
    Type: Application
    Filed: February 22, 2005
    Publication date: February 2, 2006
    Inventors: Ute Breitenbach, Stephan Gallinat, Ludger Kolbe, Claudia Mundt, Volker Schreiner, Franz Stab, Rainer Wolber, Helga Biergiesser, Heiko Mielke, Thomas Blatt, Kirsten Venzke, Kyra Sanger
  • Use of combinations of active ingredients of one or more bioquinones and one or more isoflavones for improving the contours of the skin
    Publication number: 20060002885
    Abstract: A method of tightening and/or firming the skin and a method for the treatment and/or prophylaxis of cellulite, wherein the methods comprise applying to at least a part of the skin a cosmetic or dermatological O/W emulsion which comprises one or more bioquinones and one or more isoflavonoids.
    Type: Application
    Filed: September 8, 2004
    Publication date: January 5, 2006
    Applicant: BEIERSDORF AG
    Inventors: Heiko Mielke, Soren Jaspers, Gunhild Hamer, Christopher Mummert, Jens Schulz, Stefan Gallinat, Kirsten Venzke, Frank Schwanke
  • Multicistronic expression units and their use
    Patent number: 6060273
    Abstract: Multicistronic expression units allow the equimolar expression of the genes located in the corresponding cistrons. These expression units are particularly suitable for the recombinant production of proteins composed of two or more polypeptide subunits.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: May 9, 2000
    Assignees: Beiersdorf AG, Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Wilhelm Dirks, Manfred Wirth, Hansjorg Hauser, Wolfram Eichner, Volker Achterberg, Albrecht Dorschner, Wolfgang Meyer-Ingold, Heiko Mielke
  • Cell adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other
    Patent number: 5994311
    Abstract: The invention relates to adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other and their use to promote or inhibit the cell/cell adhesion of eukaryotic cells. The invention relates in particular to the use of the cell adhesion polypeptides in the manufacture of pharmaceuticals to influence the cell/cell interactions of eukaryotic cells.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: November 30, 1999
    Assignee: Beiersdorf AG
    Inventors: Wolfram Eichner, Katharina Kock, Heiko Mielke, Albrecht Doerschner
  • Process for producing a pharmaceutical preparation of PDGF-AB
    Patent number: 5935819
    Abstract: The recombinant production of PDGF-AB in mammalian cells is disclosed by means of a bicistronic vector system in which an IRES sequence is located between the first and second cistrons and in which the B chain coding gene is located in the first cistron. The disclosed expression unit allows the equilmolar expression of the A and B polypeptide chains.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: August 10, 1999
    Inventors: Wolfram Eichner, Volker Achterberg, Albrecht Dorschner, Wolfgang Meyer-Ingold, Heiko Mielke, Wilhem Dirks, Manfred Wirth, Hansjorg Hauser
  • Preparation of heterodimeric PDGF-AB using a bicistronic vector system in mammalian cells
    Patent number: 5665567
    Abstract: The recombinant production of PDGF-AB in mammalian cells is disclosed by means of a bicistronic vector system in which an IRES sequence is located between the first and second cistrons and in which the B chain coding gene is located in the first cistron. The disclosed expression unit allows the equimolor expression of the A and B polypeptide chains.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: September 9, 1997
    Assignees: Beiersdorf AG, Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Wolfram Eichner, Volker Achterberg, Albrecht Dorschner, Wolfgang Meyer-Ingold, Heiko Mielke, Wilhem Dirks, Manfred Wirth, Hansjorg Hauser
  • DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition
    Patent number: 5457047
    Abstract: The invention relates to DNA sequences coding for PTH variants, to PTH variants, expression vectors, bacterial hosts, uses and therapeutic compositions.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: October 10, 1995
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Edgar Wingender, Heiko Mielke, Gisela Bercz-Timm, Klaus-Dieter Schluter, Hubert Mayer
  • DNA sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition
    Patent number: 5455329
    Abstract: The invention relates to DNA sequences coding for PTH variants, to PTH variants, expression vectors, bacterial hosts, uses and therapeutic compositions.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: October 3, 1995
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Edgar Wingender, Heiko Mielke, Gisela Bercz-Timm, Klaus-Dieter Schluter, Hubert Mayer