Patents by Inventor Heiner Apeler

Heiner Apeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Factor IX Polypeptides and Uses Thereof
    Publication number: 20120164130
    Abstract: The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.
    Type: Application
    Filed: August 2, 2010
    Publication date: June 28, 2012
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Alan Brooks, Chandra Patel, Xiaoqiao Jiang, Uwe Gritzan, Heiner Apeler, Jun Wang
  • Method for preparing viral material
    Patent number: 7666654
    Abstract: The invention relates to a method for preparing viral suspensions. The invention relates in particular to a method for preparing high-titer viral suspensions in cell cultures. Preferred methods include increasing the volume of the cell culture prior to infection with viral material and subsequent further steps of expanding the volume to a final volume which is distinctly larger than the maximum culture volume prior to infection.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: February 23, 2010
    Assignee: AiCuris GmbH & Co. KG
    Inventors: Michael Pohlscheidt, Berthold Boedeker, Torsten Minuth, Heiner Apeler, Uwe Langer, Katrin Brabender, Dirk Otto-Brabender, Joachim Kerper, Hans-Juergen Henzler
  • Chimeric Kunitz Domains and their Use
    Publication number: 20090170766
    Abstract: The present invention relates to chimeras of human tissue factor inhibitor domain 1 with natural and non-natural Kunitz domains, and their preparation and use.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 2, 2009
    Applicant: BAYER HEALTHCARE AG
    Inventors: Felix Oehme, Heiner Apeler, Frank Dittmer, Jürgen Franz, Axel Harrenga, Michael Sperzel, Simone Greven, Jürgen Lenz
  • Method for preparing viral material
    Publication number: 20080014626
    Abstract: The invention relates to a method for preparing viral suspensions. The invention relates in particular to a method for preparing high-titer viral suspensions in cell cultures. Preferred methods include increasing the volume of the cell culture prior to infection with viral material and subsequent further steps of expanding the volume to a final volume which is distinctly larger than the maximum culture volume prior to infection.
    Type: Application
    Filed: April 5, 2007
    Publication date: January 17, 2008
    Inventors: Michael Pohlscheidt, Berthold Boedeker, Torsten Minuth, Heiner Apeler, Uwe Langer, Katrin Brabender, Dirk Otto-Brabender, Joachim Kerper, Hans-Juergen Henzler
  • Benzofuran derivatives
    Patent number: 7015246
    Abstract: The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: March 21, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Carsten Schmeck, Ulrich Müller, Gunter Schmidt, Josef Pernerstorfer, Hilmar Bischoff, Axel Kretschmer, Verena Vöhringer, Christiane Faeste, Helmut Haning, Markus Hauswald, Delf Schmidt, Martin Zoche, Heiner Apeler, Willi Jonghaus, Peter Reinemer
  • Benzofuran derivatives
    Publication number: 20040220415
    Abstract: The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.
    Type: Application
    Filed: April 12, 2004
    Publication date: November 4, 2004
    Inventors: Carsten Schmeck, Ulrich Muller, Gunter Schmidt, Josef Pernerstorfer, Hilmar Bischoff, Axel Kretschmer, Verena Vohringer, Christiane Faeste, Helmut Haning, Markus Hauswald, Delf Schmidt, Martin Zoche, Heiner Apeler, Willi Jonghaus, Peter Reinemer
  • Plasmids, their construction and their use in the manufacture of interleukin-4 and interleukin-4 muteins
    Patent number: 6506590
    Abstract: The present invention relates to the construction and use of expression plasmids in the manufacture of recombinant interleukin-4 (IL-4) and interleukin-4 muteins.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heiner Apeler, Hermann Wehlmann
  • hIL-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
    Patent number: 6130318
    Abstract: The present invention relates to novel hIL-4 mutant proteins, to processes for preparing them, and to their use as medicaments, in particular in overshooting, falsely regulated immune reactions and autoimmune diseases.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: October 10, 2000
    Assignee: Bayer Aktiengellschaft
    Inventors: Hanno Wild, Rudolf Hanko, Michael Dorschug, Hans-Dietrich Horlein, Jurgen Beunink, Heiner Apeler, Hermann Wehlmann, Walter Sebald
  • Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
    Patent number: 5707831
    Abstract: The invention relates to a process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence, with the recombinant aprotinin and/or the recombinant aprotinin variants being present as homogeneously processed, secreted proteins.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: January 13, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heiner Apeler, Jurgen Beunink, Michael Dorschug, Uwe Gottschalk