Patents by Inventor Heiner Glombik

Heiner Glombik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
    Publication number: 20100261664
    Abstract: Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof The invention relates to substituted heterocyclic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation. The compounds are suitable for example as antidiabetics.
    Type: Application
    Filed: May 25, 2010
    Publication date: October 14, 2010
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wendelin FRICK, Heiner GLOMBIK, Werner KRAMER, Hubert HEUER, Harm BRUMMERHOP, Oliver PLETTENBURG
  • Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use
    Patent number: 7772429
    Abstract: The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: August 10, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Andreas Lindenschmidt, Stefanie Flohr, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer, Eric Galia, Heiner Glombik
  • NOVEL DIPHENYLAZETIDINONES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS AND THEIR USE
    Publication number: 20100160282
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: December 23, 2009
    Publication date: June 24, 2010
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Heiner Glombik, Werner Kramer, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schäfer
  • 6-oxazol-4-ylmetholmethoxy-alko-alkoxymethyl substituted benzoic acid derivatives forming peroxisome proliferator—activated receptor (PPAR) ligands, process for their preparation and methods of use thereof
    Patent number: 7732471
    Abstract: The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptor (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein R1-R6 are further defined herein.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: June 8, 2010
    Assignee: Sanofi-Aventis
    Inventors: Christian Stapper, Heiner Glombik, Eugen Falk, Stefanie Keil, Hans-Ludwig Schaefer, Wolfgang Wendler, Stephanie Hachtel
  • NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH FLUORINE, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF
    Publication number: 20100062991
    Abstract: This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.
    Type: Application
    Filed: May 14, 2009
    Publication date: March 11, 2010
    Applicant: SANOFI-AVENTIS DEUTUSCHLAND GMBH
    Inventors: Heiner Glombik, Wendelin Frick, Stefan Theis, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer
  • Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
    Patent number: 7674773
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: March 9, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Werner Kramer, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schäfer
  • Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Patent number: 7671047
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: March 2, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof
    Patent number: 7666848
    Abstract: Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: February 23, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Wendelin Frick, Hubert Heuer, Werner Kramer, Harm Brummerhop, Oliver Plettenburg
  • Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof
    Publication number: 20100035961
    Abstract: This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
    Type: Application
    Filed: May 14, 2009
    Publication date: February 11, 2010
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wendelin Frick, Heiner Glombik, Stefan Theis, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer
  • NOVEL 1,4-BENZOTHIEPIN-1, 1-DIOXIDE DERIVATIVES WITH IMPROVED PROPERTIES METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF
    Publication number: 20100035834
    Abstract: This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
    Type: Application
    Filed: May 14, 2009
    Publication date: February 11, 2010
    Applicant: SANOFI-AVENTIS DEUTUSCHLAND GMBH
    Inventors: Heiner Glombik, Wendelin Frick, Stefan Theis, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer
  • NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH CYCLOHEXYL GROUPS, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF
    Publication number: 20100035962
    Abstract: This Invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof.
    Type: Application
    Filed: May 14, 2009
    Publication date: February 11, 2010
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wendelin Frick, Heiner Glombik, Stefan Theis, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer
  • 1,4-benzothiazepine 1,1-dioxide derivative, process for its preparation, medicaments comprising this compound, and use thereof as a hypolipidaemic
    Patent number: 7615536
    Abstract: The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: November 10, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Wendelin Frick, Heiner Glombik, Hubert Heuer, Hans-Ludwig Schaefer, Stefan Theis
  • Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes
    Patent number: 7598281
    Abstract: The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with arylcycloalkyl-substituted alkanoic acid derivatives and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: October 6, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Christian Stapper, Eugen Falk, Stefanie Keil, Hans-Ludwig Schaefer, Wolfgang Wendler, Stephanie Knieps
  • Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Patent number: 7579339
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: August 25, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
    Patent number: 7576200
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: August 18, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Werner Krame, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schäfer
  • 2-{-3-?2-(phenyl)-oxazol-4-ylmethoxymethyl-cyclohexylmethoxy}-propionic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes
    Patent number: 7538131
    Abstract: The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: May 26, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Christian Stapper, Eugen Falk, Stefanie Keil, Hans-Ludwig Schaefer, Wolfgang Wendler, Stephanie Knieps
  • Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
    Patent number: 7488829
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: February 10, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heiner Glombik, Werner Krame, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schäfer
  • Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
    Publication number: 20080281092
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: July 17, 2008
    Publication date: November 13, 2008
    Inventors: Heiner Glombik, Werner Krame, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schafer
  • 1,3-SUBSTITUTED CYCLOALKYL DERIVATIVES HAVING ACIDIC, MOSTLY HETEROCYCLIC GROUPS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20080249126
    Abstract: The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved.
    Type: Application
    Filed: July 10, 2007
    Publication date: October 9, 2008
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Jochen Goerlitzer, Heiner Glombik, Eugen Falk, Dirk Gretzke, Stefanie Keil, Hans-Ludwig Schaefer, Christian Stapper, Wolfgang Wendler
  • Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof
    Publication number: 20080207592
    Abstract: The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.
    Type: Application
    Filed: January 7, 2008
    Publication date: August 28, 2008
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wendelin FRICK, Heiner GLOMBIK, Hubert HEUER, Hans-Ludwig SCHAEFER, Stefan THEIS