Patents by Inventor Heiner Glombik

Heiner Glombik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6291486
    Abstract: Polycyclic dihydrothiazoles, processes for their preparation, and their pharmaceutical uses are provided. Preferred compounds are represented by the formula I wherein the radicals may have various meanings. The compounds are particularly useful as anorectics.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: September 18, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Heiner Glombik, Karl Geisen, Martin Bickel
  • Patent number: 6277831
    Abstract: The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts. 1,4-Benzothiazepine-1,1-dioxide derivatives of formula 1, wherein R1, R2, R3, and Z have the meanings indicated in the specification, physiologically tolerable salts, and physiologically functional derivatives thereof, and also processes for their preparation, are described. The compounds are suitable, for example, as hypolipidemics.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: August 21, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Heiner Glombik, Hubert Heuer, Hans-Ludwig Schäfer
  • Patent number: 6245744
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: June 12, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schäfer
  • Patent number: 6221897
    Abstract: Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: April 24, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Alfons Enhsen, Heiner Glombik, Hubert Heuer
  • Patent number: 6180618
    Abstract: Compounds of formula (I) in which the radicals are as defined in the specification and claims, and physiologically tolerated and physiologically functional derivatives thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: January 30, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Siegfried Stengelin, Alfons Enhsen, Heiner Glombik, Werner Kramer, Eugen Falk
  • Patent number: 6114322
    Abstract: The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are as defined in the Specification and useful as hypolipidemic compounds.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: September 5, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Eugen Falk, Heiner Glombik, Siegfried Stengelin
  • Patent number: 6090833
    Abstract: Polycyclic dihydrothiazoles, processes for their preparation, and their pharmaceutical uses are provided. Preferred compounds are represented by the formula I ##STR1## wherein the radicals may have various meanings. The compounds are particularly useful as anorectics.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: July 18, 2000
    Assignee: Aventis Pharma Deutschand GmbH
    Inventors: Gerhard Jaehne, Heiner Glombik, Karl Geisen, Martin Bickel
  • Patent number: 6020330
    Abstract: The present invention is concerned with new hypolipidemic compounds, with processes and novel intermediates for their preparation, with pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.Compounds of the formula (I): ##STR1## wherein R.sup.1 to R.sup.10 and X are a defined in the specification and are useful as hypolipidemic compounds.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: February 1, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Eugen Falk, Heiner Glombik, Siegfried Stengelin
  • Patent number: 5874451
    Abstract: The invention relates to substituted propanolamine derivatives and their acid addition salts.Propanolamine derivatives of formula I, ##STR1## in which R.sup.1 to R.sup.8 have the meanings indicated in the specification, and their physiologically tolerable salts and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: February 23, 1999
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Heiner Glombik, Alfons Enhsen, Werner Kramer, Karl-Heinz Baringhaus
  • Patent number: 5631326
    Abstract: Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 20, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Stefan M ullner, Axel Walch
  • Patent number: 5610151
    Abstract: Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicamentsMonomeric bile acid derivatives of the formula IZ--X--GS I,in which GS, X and Z have the meanings given, and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: March 11, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heiner Glombik, Alfons Enhsen, Werner Kramer, G unther Wess
  • Patent number: 5559258
    Abstract: Ethylenically unsaturated bile acid derivatives of the formula IG--X--A Iin which G, X and A have the meanings indicated, are described. They are suitable for the preparation of polymeric bile acid derivatives. Bile acid derivatives of the formula IVaG--X' IVain which G and X' have the meanings indicated, are also described. They are useful synthesis components for the preparation of pharmaceuticals.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: September 24, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Stefan M ullner, G unther Wess
  • Patent number: 5512558
    Abstract: nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula IG1--X--G2 Iin which G1, G2 and X have the meanings given, processes for the preparation of these compounds and medicaments are described. On the basis of their pharmacological action, they can be used as an antihyperlipidemic agent.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: April 30, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Werner Kramer, Gunther Wess
  • Patent number: 5486626
    Abstract: Process for the preparation of 3.beta.-aminocholanic acid derivativesA process for the preparation of 3.beta.-aminocholanic acid derivatives of the formula II ##STR1## wherein R(1), R(2) and R(3) have the meanings given, starting from the corresponding 3.beta.-hydroxycholanic acid esters, is described.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: January 23, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Werner Kramer, Gunther Wess
  • Patent number: 5466815
    Abstract: The invention relates to tetrazole derivatives of bile acids, processes for their preparation, and use of these compounds as medicaments and cholesterol lowering agents.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: November 14, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Werner Kramer, Gunther Wess
  • Patent number: 5430110
    Abstract: Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary.Polyvinylamine derivatives containing hydrophilic centers, of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X, w, x, y and z have the meanings given, and a process for their preparation, and the use of these compounds as medicaments, active compound carriers and foodstuff auxiliaries are described. Highly pure polyvinylamines having the recurring unit of the formula Ia ##STR2## the preparation of which is likewise described, are used in particular as starting substances for the preparation.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: July 4, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Susanne Grabley, Ernold Granzer, Stefan Mullner, Axel Walch, Guan-Yu Xu
  • Patent number: 5428182
    Abstract: Bile acid derivatives of the formula IZ(X--GS)nin which GS, X, Z and n have the meanings indicated in the specification, and a process for the preparation of these compounds are described. The compounds are pharmacologically active and can, therefore, be used as pharmaceuticals, in particular as a hypolipidemic.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Werner Kramer, Gunther Wess
  • Patent number: 5428112
    Abstract: Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Stefan Mullner, Axel Walch
  • Patent number: 4943576
    Abstract: Substituted quinoxalyl-imidazolidine-2,4-diones, processes for their preparation, their use as medicaments and pharmaceutical preparations 5-Quinoxalyl-imidazolidine-2,4-diones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings given, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds inhibit aldose reductase and can be used as medicaments.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: July 24, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heiner Glombik, Roland Utz, Hans-Jochen Lang, Karl Geisen, Friedrich E. Beyhl