Abstract: An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoforma

Abstract: An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of 5-aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthofor

Abstract: A cutting tool with a linear oscillating drive has a handle body (1) and a knife (3, 4) which is guided therein and is displaceable in an oscillating manner in the longitudinal direction, the knife (3, 4), by means of a knife holder (4), being detachably connected via a clamping member to a transmission element, arranged in the handle body (1), of the linear oscillating drive. Since the knife holder (4) is cohesively connected, in particular sealed, together with a knife shaft (31), the cutting tool complies with the hygiene regulations for use in the foodstuffs sector.

Abstract: A cutting tool with a linear oscillating drive has a handle body (1) and a knife (3, 4) which is guided therein and is displaceable in an oscillating manner in the longitudinal direction, the knife (3, 4), by means of a knife holder (4), being detachably connected via a clamping member to a transmission element, arranged in the handle body (1), of the linear oscillating drive. Since the knife holder (4) is cohesively connected, in particular sealed, together with a knife shaft (31), the cutting tool complies with the hygiene regulations for use in the foodstuffs sector.

Abstract: A motor housing (11) is mounted in a handle body (10) so as to slide in the longitudinal direction. A tubular pipe (37) that can slide in a bore (38) of the body (10) projects from the back of the housing (11). Compressed air can be applied to the bore (38) through a switching valve (40). A piston (14) with a piston rod (17) can slide in the housing and a tool can be secured to its front end. A flutter valve (23) which alternatingly connects the bore (38) to the two cylinder chambers (27, 28) is built into the valve housing (22). The piston (14) alternatingly opens the connection to an outgoing air conduit (29-31). A pre-stressed spring (47) is set between the body (10) and the housing (11). In operation, the housing (11) oscillates out of step with the piston (14), so that their initial forces are largely compensated and no vibrations are transmitted to the handle body (10).

Abstract: The bifunctional compound N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide monopotassium salt occurs in a number of crystal forms which differ in their stability. Of these forms, the most stable is designated Type I, which is a monopotassium salt monohydrate in which the water is held as water of crystallization. Other crystalline forms, designated Type II and Type III, convert to Type I. Methods are disclosed for the synthesis of Type I and for the conversion of Type II or Type III to Type I.

Abstract: With the present method, a process which can be employed industrially can be used for the first time for the direct production of aminocyanoacetamide. The method is based on the reaction of cyanoacetamide with nitrites to form nitrosocyanoacetamide at a pH of around 2 and on the subsequent catalytic hydrogenation of nitrosocyanoacetamide to form aminocyanoacetamide.

Abstract: The present invention relates to a novel process for the selective debenzylation of dibenzylbiotin, which is formed as an intermediate in the synthesis of biotin, but is usually not isolated.

Abstract: The invention relates to a selective process for the preparation of N-L-.alpha.-aspartyl-L-phenylalanine-1-lower alkyl ester which comprises:A.

Abstract: A method for the synthesis of serinol and serinol derivatives substituted at the nitrogen atoms by reacting a lower 1,3-dialkoxy-isopropyl halide with ammonia or an amine to form a 1,3-dialkoxy-isopropylamine and then removing the ether groups by heating with a hydrogen halide acid. The method allows the production of serinol and serinol derivatives using inexpensive starting materials in a simple manner and obtaining a high purity product which is free of interfering isomers. Novel compounds obtained by the method which are useful as pharmaceutical intermediates, X-ray contrasting agents and cytostatic or psychopharmacological drugs are also disclosed.