Patents by Inventor Heinrich H. Coenen

Heinrich H. Coenen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of .sup.18 F-labeled organic compounds by nucleophilic substitution
    Patent number: 4794178
    Abstract: Organic compounds labeled with no-carrier-added fluorine 18 are processed yield a compound having a formula in the form of .sup.18 F-R through a nucleophilic substitution reaction. The process has a series of steps. The first step of the process relates to providing an organic compound having a formula of X-R. X is the nucleophilic leaving group in the substitution action, and R is a preferred substituted hydrocarbon structure being selected from aliphatic, alicyclic, heterocyclic aliphatic, carbocyclic and heterocyclic aromatic structures. The X-R compounds with acid hydrogen are excluded. The next step is to bring the organic compound X-R into contact with fluoride ions which are present in a solvent. These fluoride ions are essentially carrier free .sup.18 F ions. The organic compound is brought into contact with the fluoride ions in an apparatus to produce a reaction.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: December 27, 1988
    Assignee: Kernforschungsanlage Julich Gesellschaft mit beschrankter Haftung
    Inventors: Heinrich H. Coenen, Kurt Hamacher, Manfred Schuller, Gerhard Stocklin, Bernd Klatte, Arndt Knochel