Abstract: The invention relates to pharmaceutical preparations which contain a combination of a thiazide diuretic and a low-dose loop diuretic and which are particularly useful for treating hypertension and heart failure. It is not only the overall natriuretic/diuretic effects which are increased due to said combination of thiazide diuretic and loop diuretic, but the undesired secondary effects regarding potassium and magnesium losses are significantly reduced as well. As a result, the desired hypocalciuric effect of the thiazide is maintained despite the presence of the loop diuretic.

Abstract: Pteridine compounds, useful as diuretics, of the formula ##STR1## wherein R.sub.1 and R.sub.2 taken alone are, independently of each other, hydrogen, alkyl having from 1 to 6 carbon atoms, or benzyl, or wherein R.sub.1 and R.sub.2, taken together with the nitrogen atom to which they are bound, form a five- or six-membered heterocyclic ring system or such a ring containing one or two further hetero atoms, or wherein R.sub.1 and R.sub.

Abstract: Pharmaceutical compositions having a diuretic effect and containing as the active ingredient a compound of the formula ##STR1## wherein R is hydrogen, a pharmaceutically acceptable cation, methyl, or a hydrophilic group R', are disclosed, as are novel compounds wherein R is R'.This application is a continuation-in-part of application Ser. No. 860,824 filed Dec. 15, 1977, now abandoned.