Abstract: Therapeutic compositions containing a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy f 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form --OCH.sub.2 O--; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms, and the use of said compounds to control virus infections, in particular those caused by entero and foot and mouth disease viruses of the Picorna group.

Abstract: A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-aminopenicillanic acid with D(-)-.alpha.-phenylglycylchloride hydrochloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are adjusted to provide good yields of a product of high purity.