Patents by Inventor Heinrich Winfred Schlieker

Heinrich Winfred Schlieker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing a target fermentation product
    Patent number: 7695949
    Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided. The polynucleotide sequences of the present invention include sequences derived from the biotin operon of B. subtilis and in particular the bioFDB gene cassette.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: April 13, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins
  • Process for producing a target fermentation product
    Publication number: 20040063171
    Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided.
    Type: Application
    Filed: October 8, 2003
    Publication date: April 1, 2004
    Applicant: ROCHE VITAMINS, INC.
    Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins
  • Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation
    Patent number: 6656721
    Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided. The polynucleotide sequences of the present invention include sequences derived from the biotin operon of B. subtilis, and in particular the bioFDB gene cassette.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: December 2, 2003
    Assignee: Roche Vitamins, Inc.
    Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins