Publication number: 20060252767
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Application
Filed:
July 29, 2004
Publication date:
November 9, 2006
Applicant:
XENON PHARMACEUTICALS INC.
Inventors:
Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael Winther, Heins Gschwend, Rajender Kamboj, Shaoyi Sun, Mark Holladay, Wenbao Li, Chi Tu
Publication number: 20060199802
Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (1): wherein: W is —O—, —N(R1)—, C(O), S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R1)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Type:
Application
Filed:
July 29, 2004
Publication date:
September 7, 2006
Inventors:
Melwyn Abreo, Daniel Harvey, Heins Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael Winther, Vishnumurthy Kodumuru, Cindy Hudson, Mikhail Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
