Patents by Inventor Heinz Bender

Heinz Bender has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5693795
    Abstract: A process for the manufacture of 4H-imidazo?1,5-a!?1,4!benzodiazepine derivatives of formula I ##STR1## wherein R.sup.1 is phenyl or mono- or disubstituted phenyl;R.sup.2 is hydrogen, halogen, nitro, cyano, trifluoromethyl or lower alkyl;R.sup.3 is hydrogen or lower alkyl; andR.sup.4 is hydrogen or lower alkyland of pharmaceutically usable salts of these compounds by decarboxylating a 4H-imidazo?1,5-a!?1,4!benzodiazepinecarboxylic acid of formula II ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the above significances, at elevated temperature and under elevated pressure in the presence of an organic solvent. The compounds of formula I and their pharmaceutically usable acid addition salts are known muscle relaxants, sedatives and anticonvulsants.
    Type: Grant
    Filed: October 2, 1996
    Date of Patent: December 2, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karl-Heinz Bender, Manfred Breuninger, Manfred Froom, Siegfried Schmitt, Kurt Steiner
  • Patent number: 4598079
    Abstract: Aryl-substituted piperazinones and their physiologically-acceptable acid-addition salts have a useful nootropic action. They are administered enterally or parenterally in conventional dosage forms.
    Type: Grant
    Filed: May 15, 1984
    Date of Patent: July 1, 1986
    Assignee: Cassella Aktiengesellschaft
    Inventors: Rudi Beyerle, Heinz Bender, Ursula Schindler, Rolf-Eberhard Nitz, Piero A. Martorana
  • Patent number: 4485240
    Abstract: In a process for the preparation of optionally-substituted 1,2,3,4-tetrahydro-9-cyanomethylcarbazol-1-ones of the formula ##STR1## wherein R denotes hydrogen, halogen, alkyl or alkoxy, by cyano-methylating optionally substituted 1,2,3,4-tetrahydrocarbazol-1-ones of the formula ##STR2## wherein R has the meanings mentioned above, the starting material of formula II is reacted, in a two-phase system consisting of water and a water-immiscible organic solvent, in the presence of a strong base and a known phase transfer catalyst, with a cyanomethylating agent of the formulaR.sup.1 --CH.sub.2 --CN (III),wherein R.sup.1 denotes halogen or a radical of the formula R.sup.2 --SO.sub.2 --O-- and R.sup.2 represents alkyl, phenyl or substituted phenyl.
    Type: Grant
    Filed: April 19, 1983
    Date of Patent: November 27, 1984
    Assignee: Cassella Aktiengesellschaft
    Inventors: Heinz Bender, Veit Buch, Rudi Beyerle, Klaus Kuhlein
  • Patent number: 4271073
    Abstract: The present invention relates to new, pharmacologically valuable 2,4,5,6-tetrahydro-1H-pyrazino-[3,2,1-jk]-carbazoles substituted in the 8-position having the formula I ##STR1## wherein R stands for an alkyl or alkoxy group having 1 to 4 carbon atoms or a fluorine, chlorine or bromine atom comprising reacting a 6,9-disubstituted 1,2,3,4-tetrahydrocarbazol-1-one of the formula II ##STR2## and X denotes a bromine, chlorine or iodine atom or the radical of the formula defined --O--SO.sub.2 --R' and R' is an alkyl radical having 1 to 3 carbon atoms, phenyl or tolyl, with ammonia.
    Type: Grant
    Filed: November 29, 1979
    Date of Patent: June 2, 1981
    Assignee: Cassella Aktiengesellschaft
    Inventors: Heinz Bender, Rudi Beyerle, Karl-Heinz Keil, Heinz G. Greve, Kuno Reh
  • Patent number: 4263727
    Abstract: In a sheet for the manufacture of cushioned insoles or of inner soles comprising a substrate and a foamed plastic layer the improvement wherein said substrate comprises a bonded fibrous web flame laminated to the foamed plastic layer which comprises a closed-cell crosslinked polyolefin foam. Advantageously a woven covering layer is flame laminated to the opposite surface of the polyolefin foam which comprises polyethylene and has a density of about 25 to 200 kg/m.sup.3 and a thickness of about 1.5 to 15 mm.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: April 28, 1981
    Assignee: Firma Carl Freudenberg
    Inventors: Heinz Bender, Hans-Dietrich Krug, Klaus Heckel
  • Patent number: 4258043
    Abstract: The present invention relates to new, pharmacologically-valuable antidepressants, which are 2,4,5,6-tetrahydro-1H-pyrazino-[3,2,1-jk]-carbazoles substituted in the 8-position and having the formula I ##STR1## wherein R stands for an alkyl or alkoxy group having 1 to 4 carbon atoms or a fluorine, chlorine or bromine atom, and a method for making them by reacting with ammonia a 6,9-disubstituted 1,2,3,4-tetrahydrocarbazol-1-one of the formula II ##STR2## wherein X denotes a bromine, chlorine or iodine atom or a radical of the formula --O--SO.sub.2 --R', and R' is an alkyl radical having 1 to 3 carbon atoms, phenyl or tolyl.
    Type: Grant
    Filed: November 29, 1979
    Date of Patent: March 24, 1981
    Assignee: Cassella Aktiengesellschaft
    Inventors: Heinz Bender, Rudi Beyerle, Steffen Piesch, Piero A. Martorana
  • Patent number: 3987036
    Abstract: The present invention relates to new pharmacologically valuable, basically substituted heterocyclic compounds of the formula ##EQU1## wherein X represents--N=N----ch=n-- ##EQU2## R represents an aliphatic, cycloaliphatic, araliphatic or aromatic amine radical having 2 to 10 carbon atoms or the radical of a 5, 6 or 7 ring-membered heterocyclic amine optionally containing an additional N, O or S hetero atom, the radical being attached through the nitrogen atom,R.sub.1 and R.sub.2 represent alkoxy groups containing 1 - 4 C-atoms, R.sub.3 represents lower alkyl having 1 - 3 C-atoms and m and n are 1, 2 or 3.The above derivatives are produced by acylating heterocyclic derivatives having the formula ##STR1## with an alkoxycinnamic acid of the general formula ##STR2## OR A FUNCTIONAL DERIVATIVE OF THE LATTER, OPTIONALLY IN THE PRESENCE OF AN ACID-BINDING AGENT, THE RADICALS R, R.sub.1, R.sub.2, n and m having the meanings set out above.
    Type: Grant
    Filed: July 15, 1974
    Date of Patent: October 19, 1976
    Assignee: Cassella Farbwerke Mainkur Aktiengesellschaft
    Inventors: Heinz Bender, Otto Grawinger, Adolf Stachel, deceased, by Ingeburg Lydia Katharina Stachel, heiress, Rudi Beyerle, Josef Scholtholt, Rolf-Eberhard Nitz