Patents by Inventor Heinz Ernst Moser
Heinz Ernst Moser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11117915Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: November 8, 2019Date of Patent: September 14, 2021Assignee: CIPLA USA, INC.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 10919887Abstract: The invention provides new solid forms, salts and polymorphs of 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to herein as Compound X), pharmaceutical compositions containing them, and processes for their manufacture and use in therapy.Type: GrantFiled: September 20, 2016Date of Patent: February 16, 2021Assignee: Novartis AGInventors: Eric Aubin, Anthony Casarez, Andreas Fisch, Zaixing Li, Mika Lindvall, Heinz Ernst Moser, Michael Mutz, Folkert Reck, Bernd Ulrich Riebesehl, Marc Schoenhentz, Vijay Sethuraman, Robert Lowell Simmons
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Publication number: 20200317709Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: November 8, 2019Publication date: October 8, 2020Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Publication number: 20200276169Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: ApplicationFiled: March 19, 2020Publication date: September 3, 2020Inventors: Virender Singh AULAKH, Anthony CASAREZ, Xiaodong LIN, Mika LINDVALL, Glenn MCENROE, Heinz Ernst MOSER, Folkert RECK, Meiliana TJANDRA, Robert Lowell SIMMONS, Aregahegn YIFRU, Qingming ZHU
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Patent number: 10369138Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: GrantFiled: September 22, 2015Date of Patent: August 6, 2019Assignee: Novartis AGInventors: Virender Singh Aulakh, Anthony Casarez, Xiaodong Lin, Mika Lindvall, Glenn McEnroe, Heinz Ernst Moser, Folkert Reck, Meiliana Tjandra, Robert Lowell Simmons, Aregahegn Yifru, Qingming Zhu
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Publication number: 20190231752Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Inventors: Virender Singh AULAKH, Anthony CASAREZ, Xiaodong LIN, Mika LINDVALL, Glenn MCENROE, Heinz Ernst MOSER, Folkert RECK, Meiliana TJANDRA, Robert Lowell SIMMONS, Aregahegn YIFRU, Qingming ZHU
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Publication number: 20180318311Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of bacterial infections, and have the structure of Formula (I): as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Guillaume LAPOINTE, Wosenu MERGO, Heinz Ernst MOSER, Alexey RIVKIN, Colin Keith SKEPPER, Sarah Louise Williams
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Publication number: 20180273522Abstract: The invention provides new solid forms, salts and polymorphs of 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to herein as Compound X), pharmaceutical compositions containing them, and processes for their manufacture and use in therapy.Type: ApplicationFiled: September 20, 2016Publication date: September 27, 2018Inventors: Eric AUBIN, Anthony CASAREZ, Andreas FISCH, Zaixing LI, Mika LINDVALL, Heinz Ernst MOSER, Michael MUTZ, Folkert RECK, Bernd Ulrich RIEBESEHL, Marc SCHOENHENTZ, Vijay SETHURAMAN, Robert Lowell SIMMONS
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Patent number: 9688711Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: January 20, 2016Date of Patent: June 27, 2017Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Publication number: 20170088549Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.Type: ApplicationFiled: December 12, 2016Publication date: March 30, 2017Inventors: Heinz Ernst MOSER, Qing LU, Phillip A. PATTEN, Dan WANG, Ramesh Annasaheb KASAR, Stephen W. KALDOR, Brian D. PATTERSON
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Publication number: 20160368942Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: January 20, 2016Publication date: December 22, 2016Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Publication number: 20160051523Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: ApplicationFiled: September 22, 2015Publication date: February 25, 2016Applicant: NOVARTIS AGInventors: Virender Singh AULAKH, Anthony CASAREZ, Xiaodong LIN, Mika LINDVALL, Glenn MCENROE, Heinz Ernst MOSER, Folkert RECK, Meiliana TJANDRA, Robert Lowell SIMMONS, Aregahegn YIFRU, Qingming ZHU
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Patent number: 9266919Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: July 17, 2014Date of Patent: February 23, 2016Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 9174978Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: GrantFiled: March 23, 2015Date of Patent: November 3, 2015Assignee: Novartis AGInventors: Virender Singh Aulakh, Anthony Casarez, Xiaodong Lin, Mika Lindvall, Glenn McEnroe, Heinz Ernst Moser, Folkert Reck, Meiliana Tjandra, Robert Lowell Simmons, Aregahegn Yifru, Qingming Zhu
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Publication number: 20150266867Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.Type: ApplicationFiled: March 23, 2015Publication date: September 24, 2015Applicant: NOVARTIS AGInventors: Virender Singh AULAKH, Anthony CASAREZ, Xiaodong LIN, Mika LINDVALL, Glenn MCENROE, Heinz Ernst MOSER, Folkert RECK, Meiliana TJANDRA, Robert Lowell SIMMONS, Aregahegn YIFRU, Qingming ZHU
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Publication number: 20150045317Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: July 17, 2014Publication date: February 12, 2015Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 8822424Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: January 4, 2013Date of Patent: September 2, 2014Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 8383596Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: June 18, 2009Date of Patent: February 26, 2013Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Patent number: 8372813Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: April 7, 2011Date of Patent: February 12, 2013Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
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Patent number: 8367625Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: April 7, 2011Date of Patent: February 5, 2013Assignee: Achaogen, Inc.Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
