Patents by Inventor Heinz Gries

Heinz Gries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5681543
    Abstract: Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuable complexing agents and complexes for diagnosis.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: October 28, 1997
    Assignee: Shering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Julius Deutsch, Heinz Gries, Jurgen Conrad, Reinhard Neumeier
  • Patent number: 5674467
    Abstract: Porphyrin complex compounds consisting of a meso-tetraphenylporphyrin ligand of general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have varying meanings, and an ion of an element of atomic numbers 21-32, 38, 39, 42-51 or 58-83 as well as optionally one or more physiologically harmless cation(s) of inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic agents.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: October 7, 1997
    Assignee: Institut fur Diagnostikforschung GmbH
    Inventors: Franz Karl Maier, Wolfgang Ebert, Mary Lee-Vaupel, Heinz Gries, Jurgen Conrad
  • Patent number: 5654467
    Abstract: The invention relates to a process for the production of C-substituted diethylenetriamines of general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings.
    Type: Grant
    Filed: October 12, 1995
    Date of Patent: August 5, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Orlin Petrov, Jean-Claude Hilscher, Klaus Nickisch, Heribert Schmitt-Willich, Heinz Gries, Bernd Raduchel, Johannes Platzek
  • Patent number: 5650136
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: July 22, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Patent number: 5648063
    Abstract: A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: July 15, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Douwe Rosenberg, Hanns-Joachim Weinmann, Ulrich Speck, Wolfgang Mutzel, Georg-Alexander Hoyer, Heinrich Pfeiffer, deceased, Franz-Josef Renneke
  • Patent number: 5595725
    Abstract: A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: January 21, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Douwe Rosenberg, Hanns-Joachim Weinmann, Ulrich Speck, Wolfgang M utzel, Georg-Alexander Hoyer, Heinrich Pfeiffer, deceased, Franz-Josef Renneke
  • Patent number: 5560903
    Abstract: A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 1, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Douwe Rosenberg, Hanns-Joachim Weinmann, Ulrich Speck, Wolfgang Mutzel, Georg-Alexander Hoyer, Heinrich Pfeiffer, Franz-Josef Renneke
  • Patent number: 5482700
    Abstract: 1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4,X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83,R.sup.1 and R.sup.2, being different, mean in each case a hydrogen atom or a straight-chain, branched, saturated or unsaturated C.sub.0 -C.sub.20 -alkylene group which optionally contains imino, phenylenoxy, phenylenimino, amido, hydrazido, ester group(s), oxygen, sulfur and/or nitrogen atom(s) and is substituted, if desired, by hydroxy, mercapto, imino, epoxy, oxo, thioxo and/or amino group(s), this alkylene group exhibiting at the end either a second molecule of general Formula I.sub.A or I.sub.B ##STR2## a functional group, or, linked by way of this functional group, a bio- or macromolecule,are valuable diagnostic and therapeutic media.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: January 9, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Julius Deutsch, Heinz Gries, Erich Klieger, Ulrich Niedballa, Franz-Josef Renneke, Juergen Conrad, Wolfgang Muetzel
  • Patent number: 5419894
    Abstract: Compounds of the general formula I: ##STR1## wherein R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## and X represents hydrogen atoms and/or metal ion equivalents, and their salts with physiologically harmless organic bases, are valuable complexing agents, complexes and complex salts for diagnostic imaging.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: May 30, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Franz-Josef Renneke, Hanns-Joachim Weinmann
  • Patent number: 5410043
    Abstract: A new process for the production of mono-N-substituted tetraaza macrocycles, N-substituted-tri-N-carboxyalkyl tetraaza macrocycles, and/or metal complexes thereof is described.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: April 25, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heinz Gries
  • Patent number: 5403572
    Abstract: The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: April 4, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Bernd Raduchel, Johannes Platzek, Hanns-Joachim Weinmann, Wolf-Rudiger Press, Ulrich Speck
  • Patent number: 5399340
    Abstract: Complex compounds of general Formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of at least one element of atomic numbers 21-29, 42, 44 or 58-70, with at least two of the substituents X representing a metal ion equivalent, andR.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and n are defined herein, as well as their salts with organic and/or inorganic bases, are valuable compounds for organ-specific NMR diagnostics.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: March 21, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Bernd Raduchel, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Jurgen Conrad
  • Patent number: 5386028
    Abstract: A process for the production of N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetrade cane derivatives and their metal complexes is described.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: January 31, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulf Tilstam, Helmut Borner, Klaus Nickisch, Heinz Gries, Johannes Platzek
  • Patent number: 5364614
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: November 21, 1990
    Date of Patent: November 15, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Patent number: 5362475
    Abstract: A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: November 8, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Douwe Rosenberg, Hanns-Joachim Weinmann, Ulrich Speck, Wolfgang Mutzel, Georg-Alexander Hoyer, Heinrich Pfeiffer, deceased, Franz-Josef Renneke
  • Patent number: 5334371
    Abstract: The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
    Type: Grant
    Filed: July 6, 1992
    Date of Patent: August 2, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Bernd Raduchel, Johannes Platzek, Hanns-Joachim Weinmann, Wolf-Rudiger Press, Ulrich Speck
  • Patent number: 5316756
    Abstract: Compounds of the general formula I: ##STR1## R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## wherein j signifies the numbers 1 to 4 and R.sup.
    Type: Grant
    Filed: April 13, 1990
    Date of Patent: May 31, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Franz-Josef Renneke, Hanns-Joachim Weinmann
  • Patent number: 5284647
    Abstract: Porphyrin complex compounds, consisting of a mesotetraphenylporphyrin ligand, optionally at least one ion of an element with atomic numbers 13, 21, 32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic and therapeutic agents.
    Type: Grant
    Filed: January 9, 1992
    Date of Patent: February 8, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Hanns-Joachim Weinmann, Heinz Gries, Jurgen Conrad, Sabina Hofmann, Ulrich Speck
  • Patent number: 5277895
    Abstract: Tetraazacyclododecane compounds of general formula I ##STR1## in which E and Q are defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable pharmaceutical agents.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: January 11, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heinz Gries, Hanns-Joachim Weinmann, Wolf-Rudiger Press, Hubert Vogler
  • Patent number: 5275801
    Abstract: Porphyrin complex compounds consisting of at least one porphyrin ligand, optionally at least one ion of an element of atomic numbers 5, 13, 21-32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic media and therapeutic agents.
    Type: Grant
    Filed: August 11, 1989
    Date of Patent: January 4, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Heinz Gries, Jurgen Conrad, Ulrich Speck