Patents by Inventor Heinz Höfler

Heinz Höfler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A METHOD FOR PREDICTING A BREAST CANCER PATIENT'S RESPONSE TO ANTHRACYCLINE TREATMENT
    Publication number: 20200181712
    Abstract: The present invention relates to a method for predicting a breast cancer patient's response to anthracycline treatment.
    Type: Application
    Filed: May 19, 2017
    Publication date: June 11, 2020
    Inventors: Manfred Schmitt, Rudolf Napieralski, Elisabeth Schüren, Michaela Aubele, Magdalena Absmaier, Eva Gross, Tibor Schuster, Heinz Höfler, Marion Kiechle
  • Markers for the prediction of outcome of anthracycline treatment
    Patent number: 10053735
    Abstract: The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: August 21, 2018
    Assignee: THERAWIS DIAGNOSTICS GMBH
    Inventors: John Foekens, John W. Martens, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frederique Spyratos, Nadia Harbeck, Manfred Schmitt, Heinz Hoefler, Sabine Maier, Gunter Weiss, Ralf Lesche, Thomas Hildmann, Achim Plum
  • Methods for the prognosis of breast cancer
    Patent number: 9017944
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: April 28, 2015
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth Lukas, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders
    Publication number: 20120184455
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 19, 2012
    Applicant: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime P. Look, Almuth Marx, Heinz Hoefler
  • Method for determining risk of relapse of breast cancer following tamoxifen adjuvant therapy
    Patent number: 8101359
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: January 24, 2012
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime P. Look, Almuth Marx, Heinz Hoefler
  • MARKERS FOR THE PREDICTION OF OUTCOME OF ANTHRACYCLINE TREATMENT
    Publication number: 20090111707
    Abstract: The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
    Type: Application
    Filed: September 21, 2006
    Publication date: April 30, 2009
    Applicant: Epigenomics AG
    Inventors: John Foekens, John Martens, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frederique Spyratos, Nadia Harbeck, Manfred Schmitt, Heinz Hoefler, Sabine Maier, Gunter Weiss, Ralf Lesche, Thomas Hildmann, Achim Plum
  • Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders
    Publication number: 20080254447
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: December 13, 2004
    Publication date: October 16, 2008
    Applicant: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Method and nucleic acids for the improved treatment of breast cell proliferative disorders
    Publication number: 20060121467
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Application
    Filed: October 1, 2003
    Publication date: June 8, 2006
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John Martens, Fabian Model, Inko Nimmrich, Tamas Rujan, Armin Schmitt, Manfred Schmitt, Maxime Look, Almuth Marx, Heinz Hoefler
  • Process for preparing adhesives having improved adhesion
    Patent number: 6616798
    Abstract: The invention provides a process for preparing adhesives having improved adhesion, in the form of their aqueous dispersions or water-redispersible dispersion powders, by emulsion polymerization in the presence of polyvinyl alcohol with or without drying of the dispersion obtainable by this process, which comprises polymerizing a comonomer mixture comprising a) one or more monomers from the group consisting of the vinyl esters of unbranched and branched carboxylic acids of 1 to 10 carbon atoms, the esters of acrylic acid and methacrylic acid with branched and unbranched alcohols of 1 to 12 carbon atoms, vinylaromatic compounds, vinyl halides and alpha-olefins, and b) from 0.01 to 50% by weight, based on the overall weight of the comonomers, of a vinyl ester of alpha-branched tertiary monocarboxylic acids of 11 carbon atoms, in the presence of c) from 0.1 to 15% by weight, based on the overall weight of the comonomers, of polyvinyl alcohol.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: September 9, 2003
    Assignee: Wacker-Chemie GmbH
    Inventors: Thomas Koehler, Heinz Hoefler
  • Probe for the early detection of displasias in multilayer tesselated epithelium and for the diagnosis and therapy of carcinomas
    Patent number: 6514712
    Abstract: The present invention provides a monoclonal or polyclonal antibody which specifically binds the Pax9 antigen as well as methods for using the same.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: February 4, 2003
    Assignee: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Heiko Peters, Rudolf Balling, Heinz Höfler, Thomas Richter
  • Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors
    Patent number: 6447776
    Abstract: The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the detection and for the therapy of diffuse gastric carcinomas.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: September 10, 2002
    Assignee: GSF Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Heinz Höfler, Karl-Friedrich Becker, Elisabeth Kremmer, Manfred Eulitz, Christoph Schuhmacher
  • Process for preparing adhesives having improved adhesion
    Publication number: 20020069965
    Abstract: The invention provides a process for preparing adhesives having improved adhesion, in the form of their aqueous dispersions or water-redispersible dispersion powders, by emulsion polymerization in the presence of polyvinyl alcohol with or without drying of the dispersion obtainable by this process, which comprises polymerizing a comonomer mixture comprising
    Type: Application
    Filed: October 24, 2001
    Publication date: June 13, 2002
    Applicant: Wacker-Chemie GmbH
    Inventors: Thomas Koehler, Heinz Hoefler
  • Method and equipment for powder spray coating
    Patent number: 6217654
    Abstract: Powder spray coating equipment includes a spraying system (2), an injector (26) to pneumatically convey powder to the spraying system (2), and at least one flushing-air intake (73) to supply flushing compressed air into the air/powder path at a flushing-air supply site where the flow impedance to the flushing compressed air is less everywhere in the downstream direction through the spraying system (2) than in the upstream direction as far as through the injector (26) in order to drive flushing compressed air from the flushing air intake (73) through the air/powder path and out of the spraying system (2).
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: April 17, 2001
    Assignee: ITW Gema AG
    Inventors: Felix Mauchle, Heinz Höfler