Patents by Inventor Heinz Hanel

Heinz Hanel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5958413
    Abstract: A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1(5-oxo-hexyl)xanthine (known as Pentoxifylline or TRENTAL) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanized recombinant antibody or fragment.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: September 28, 1999
    Assignees: Celltech Limited, Hoechst Aktiengesellschaft
    Inventors: Hiristo Anagnostopulos, Ulrich Gebert, Heinz Hanel, Michael Limbert, Mark William Bodmer, Gerald Anthony Higgs
  • Patent number: 5824874
    Abstract: The polypeptide with the sequence (SEQ ID NO:1)Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Al a-Lys-Cys-Glu-Phe-Asp-Ser-Tyr-Lys-Gly-Lys-Cys-Tyr-Cyscan be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 20, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
  • Patent number: 5589624
    Abstract: The polypeptide with the sequence (SEQ ID NO: 1)______________________________________ Ala--Thr--Tyr--Asn--Gly--Lys--Cys--Tyr--Lys--Lys--Asp-- Asn--Ile--Cys--Lys--Tyr--Lys--Ala--Gln--Ser--Gly--Lys-- Thr--Ala--Ile--Cys--Lys--Cys--Tyr--Val--Lys--Lys--Cys-- Pro--Arg--Asp--Gly--Ala--Lys--Cys--Glu--Phe--Asp--Ser-- Tyr--Lys--Gly--Lys--Cys--Tyr--Cys ______________________________________can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: December 31, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
  • Patent number: 5494658
    Abstract: The invention relates to cosmetic preparations which have a content of compounds of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are identical or different and are hydrogen or alkyl with 1 to 4 carbon atoms, where R.sup.1 and R.sup.3 are preferably hydrogen and R.sup.2 is preferably methyl,X is S or O,Y is hydrogen or up to two halogen atoms, preferably chlorine and/or bromine,Z is a single bond or the divalent radicals 0, S, --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --CH.sub.2 --S--, --S--CH.sub.2 -- or --CH.dbd.CH--CH.sub.2 --O--,Ar is an aromatic ring system which has up to two rings and which can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl and trifluoromethoxy,and/or their salts.The invention furthermore relates to the use of these cosmetic preparations as antidandruff composition and deodorant cosmetic composition.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: February 27, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz Hanel, Waltraud Simsch, Alwin K. Reng
  • Patent number: 5421839
    Abstract: Antifungal polypeptide and process for its productionThe polypeptide with the sequence (SEQ ID NO: 1)Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys- Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser-Ty r-Lys-Gly-Lys-Cys-Tyr-Cyscan be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: June 6, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
  • Patent number: 5118500
    Abstract: Pharmaceuticals which contain a substance releasing tumor necrosis factor (TNF) are better tolerated and can be given in higher doses when they contain a TNF inhibitor, especially a xanthine derivative.
    Type: Grant
    Filed: May 25, 1989
    Date of Patent: June 2, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz Hanel, Elmar Schrinner
  • Patent number: 4870088
    Abstract: Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides.They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent).The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: September 26, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ernst Blume, Wolfgang Schaper, Heinz Ehrhardt, Wolfgang Raether, Walter Dittmar, Heinz Hanel, Burkhard Sachse
  • Patent number: 4859670
    Abstract: Compounds of the formula I ##STR1## in which A equals CH or N, Ar equals phenyl, naphthyl or thienyl, R.sup.1 equals alkyl or halogen, and Y is a number of nitrogen-containing heterocyclic rings, have an excellent antimycotic action.The compounds IIIa ##STR2## are valuable intermediates for the preparation thereof.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: August 22, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Dieter Kampe, Wolfgang Raether, Walter Dittmar, Heinz Hanel
  • Patent number: 4824846
    Abstract: Compounds I ##STR1## where A equals CH or N; Ar equals naphthyl, thienyl or phenyl; R.sup.1 equals alkyl, F or Cl; g equals zero, 1 or 2; and Y equals various heterocyclic bases, and the acid-addition salts thereof, are described.Several preparation processes are described.The compounds IIIa ##STR2## where R.sup.1, g and Y are as specified in the case of the formula I, serve as intermediates for the preparation of these compounds. Processes are also specified for the preparation of IIIa.I represent valuable antimycotics.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: April 25, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus D. Kampe, Wolfgang Raether, Walter Dittmar, Heinz Hanel
  • Patent number: 4797409
    Abstract: New 1-hydroxy-2-pyridones of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R.sup.1 and R.sup.3 preferably being hydrogen, and R.sup.2 preferably being methyl,X denotes S or, preferably, O,Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine,Z denotes a single bond or the bivalent radicals O, S, --CR.sub.2 -- (R=H or C.sub.1 -C.sub.4 -alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C.sub.1 -C.sub.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: January 10, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Lohaus, Walter Dittmar, Heinz Hanel, Wolfgang Raether, Dieter Reuschling, Bengt-Thomas Grobel
  • Patent number: 4472307
    Abstract: An improved process for the preparation of azo dyestuffs of the formula ##STR1## comprising diazotizing a 2-halo-4-nitroaniline at 10.degree. to 35.degree. C. in 70 to 100 percent by weight strength acetic acid by means of nitrosylsulphuric acid, adjusting the acetic acid content of the resulting diazo solution to 60 to 85% by the addition of water, and at a temperature from 15.degree. to 45.degree. C. adding an appropriate carbazole to the diazo solution as a solid or in the form of a suspension in 60 to 100 percent strength by weight acetic acid and coupling the carbazole to the diazotized amine to produce said azo dyestuff and isolating the dyestuff.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: September 18, 1984
    Assignee: Cassella Aktiengesellschaft
    Inventors: Ulrich Buhler, Wolfgang Bodenstedt, Heinz Hanel, Eberhardt Hebestreit, Horst Tappe