Abstract: The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

Abstract: An esterase isolated from Aspergillus oryzae is capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology to known amino acid sequences.

Abstract: A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EOXPOY wherein EO is ethylene oxide, PO is propylene oxide, x=1−99%, y=1−99%, x+y=100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.

Abstract: An esterase isolated from Aspergillus oryzae is capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology to known amino acid sequences.

Abstract: The present invention relates to an enzymatic composition capable of killing or inhibiting microbial cells or micro-organisms, e.g. in laundry, on hard surfaces, in water systems, on skin, on teeth or on mucous membranes. The present invention also relates to the use of said enzymatic composition for preserving food products, cosmetics, paints, coatings, etc.

Abstract: The present invention relates to modified enzymes comprising an enzyme and at least one polyanionic domain, e.g. polyglutamic acid, polyaspartic acid or a polycarboxylic acid, wherein the enzyme comprises or is covalently attached to each said polyanionic domain. The present invention also relates to oral care compositions comprising such modified enzymes and use of the oral care compositions for preventing or treating dental disease, in particular for preventing or removing plaque. The modified enzymes are able to bind to hydroxylapatite in teeth.

Abstract: The present invention relates to an enzymatic composition capable of killing or inhibiting microbial cells or micro-organisms, e.g. in laundry, on hard surfaces, in water systems, on skin, on teeth or on mucous membranes. The present invention also relates to the use of said enzymatic composition for preserving food products, cosmetics, paints, coatings, etc.

Abstract: The present invention provides methods and compositions for bleaching a dye in solution comprising contacting, in an aqueous solution, the dye with a composition comprising a laccase and an enhancing agent of the formula: in which A is: and B is H, or C1-C4 unbranched alkyl wherein said alkyl may contain ether groups, and one, two, three, four of R2, R3, R4, R5 and R6 are H, NH2, COOH, SO3H, CN, CH3, COCH3, NO2, OCH3, NR7R8, COOR9, or NOH—CO—R10, wherein R7, R8, R9 and R10 are C1-C2 unbranched alkyl, and one, two, three, four or five of R2, R3, R4, R5 and R6 is NH2, COOH, SO3H, CN, CH3, COCH3, NO2, OCH3, NR7R8, COOR9, or NOH—CO—R10, wherein R7, R8, R9 and R10 are C1-C2 unbranched alkyl.

Abstract: The present invention relates to modified polypeptides with reduced respiratory allergenicity having polymeric molecules with a molecular weight from 100 up to 750 Da, coupled covalently to the parent polypeptide having a molecular weight from 5 to 100 kDa. The present invention also relates to industrial compositions comprising modified polypeptide with reduced respiratory allergenicity, skin care products, the use of modified polypeptides for reducing the allergenicity of industrial composition and products and finally a method for reducing the allergenicity of polypeptides.