Patents by Inventor Heinz-Jurgen Thiel

Heinz-Jurgen Thiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTANT PESTIVIRUS WITH MUTATIONS IN CORE GENE AND NS3 REGION
    Publication number: 20110229520
    Abstract: The present invention relates to mutant Pestiviruses, and vaccines containing said viruses.
    Type: Application
    Filed: September 16, 2009
    Publication date: September 22, 2011
    Inventors: Heinz-Jurgen Thiel, Hans Tillmann Ruemenapf, Manuela Heimann
  • Pestivirus mutants and vaccines containing the same
    Patent number: 7037508
    Abstract: The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5? nontranslated region of the viral genome. These mutant viruses are useful as live vaccines in the control of bovine viral diarrhea, border disease and classical swine fever.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: May 2, 2006
    Assignee: Akzo Nobel NV
    Inventors: Heinz-Jürgen Thiel, Paul P. Becher, Michaela M. Orlich
  • Production of proteins by autoproteolytic cleavage
    Publication number: 20040215008
    Abstract: The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is autoproteolytically cleaved from an expressed fusion protein which comprises a polypeptide with the autoproteolytic activity of an autoprotease Npro of a pestivirus and the heterologous polypeptide by the Npro autoproteolytic activity.
    Type: Application
    Filed: January 23, 2004
    Publication date: October 28, 2004
    Inventors: Tillmann Rumenapf, Heinz Jurgen Thiel, Jorg Windisch, Franz Knauseder
  • Antibodies and diagnostic methods for the diagnosis of pestiviruses
    Patent number: 6455264
    Abstract: The present invention relates to a diagnostic method for the diagnosis of Pestivirus infection in animals, in particular to a method for the diagnosis of animals infected with BVDV. A monoclonal antibody directed to a conserved antigen determinant on the Pestivirus ERNS protein is provided which allows the identification of infected animals with a high sensitivity and specificity.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: September 24, 2002
    Assignee: Akzo Nobel N.V.
    Inventors: Judith Baumeister, Robert Stark, Matthias König, Heinz-Jürgen Thiel
  • Immunogenic composition against Classical Swine Fever Virus (CSFV)
    Patent number: 5965134
    Abstract: This application is concerned with immunogenic polypeptides of pestiviruses, specifically Classical Swine Fever Virus (CVFV), specifically the nonstructural protein p10, more specifically T-cell epitopes from this protein and nucleic acid molecules encoding these polypeptides, and vaccines and diagnostics with these polypeptides or nucleic acid molecules.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: October 12, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Heinz-Jurgen Thiel, Knut Elbers, Thomas Pauly
  • Hog cholera virus vaccine and diagnostic
    Patent number: 5935582
    Abstract: The present invention is concerned with a hog cholera virus vaccine comprising a polypeptide characteristic of hog cholera virus. Vector vaccines capable to express a nucleic acid sequence encoding such a polypeptide also from part of the present invention. Said polypeptide and nucleic acid sequence can also be used for the detection of hog cholera virus infection.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: August 10, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Gregor Meyers, Tillmann Rumenapf, Heinz-Jurgen Thiel
  • Hog cholera virus vaccine and diagnostic
    Patent number: 5925360
    Abstract: The present invention is concerned with a hog cholera virus vaccine comprising a polypeptide characteristic of hog cholera virus. Vector vaccines capable to express a nucleic acid sequence encoding such a polypeptide also form part of the present invention. Said polypeptide and nucleic acid sequence can also be used for the detection of hog cholera virus infection.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: July 20, 1999
    Assignee: Akzo Nobel N.V.
    Inventors: Gregor Meyers, Tillmann Rumenapf, Heinz-Jurgen Thiel
  • Hog cholera virus vaccine and diagnostic
    Patent number: 5811103
    Abstract: The present invention is concerned with a hog cholera virus vaccine comprising a polypeptide characteristic of hog cholera virus. Vector vaccines capable to express a nucleic acid sequence encoding such a polypeptide also form part of the present invention. Said polypeptide and nucleic acid sequence can also be used for the detection of hog cholera virus infection.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: September 22, 1998
    Assignee: Akzo Nobel N.V.
    Inventors: Gregor Meyers, Tillmann Rumenapf, Heinz-Jurgen Thiel