Patents by Inventor Heinz Redl
Heinz Redl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110172703Abstract: A tissue sealant applicator system includes a tissue sealant applicator having an elongate body forming a bore containing a tissue sealant component, a piston, and a spray adaptor in fluid communication with the bore and forming a gas flow path. The system also includes a control unit adapted to be connected to a gas source, and a first gas passageway connecting the gas flow path and the control unit. The applicator includes an actuating member cooperatively associated with the piston to eject the tissue sealant from the bore upon user actuation. The control unit is adapted to supply gas from the gas source to the first gas passageway essentially simultaneously with user actuation of the actuating member, and to permit the supply of gas to the spray adaptor from the gas source to continue to flow for a predetermined time delay after the user stops actuating the actuating member.Type: ApplicationFiled: March 21, 2011Publication date: July 14, 2011Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Heinz Redl, Zafar Khakpour, Scott R. Ariagno, Andreas Kellner, Lillian G. Zakarija
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Patent number: 7909267Abstract: An applicator includes a bore for containing a sealant component, a piston moveably positioned in the bore, a plunger member connected to the piston with a distal end disposed within the bore and a proximal end depending from the bore, a distal outlet communicating with the bore and connectable to a gas source, and an actuating member carried by the proximal end of the plunger member to move with the plunger member as the plunger member moves along the bore. The applicator may be used in a system with a gas source connected to the distal outlet, and a control unit connected to the actuating member and the gas source, the control unit adapted to supply gas to the distal outlet from the gas source essentially simultaneous with a force applied to the actuating member.Type: GrantFiled: February 20, 2009Date of Patent: March 22, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Heinz Redl, Zafar Khakpour, Scott R. Ariagno, Andreas Kellner, Lillian G. Zakarija
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Patent number: 7892802Abstract: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.Type: GrantFiled: October 16, 2008Date of Patent: February 22, 2011Assignee: Baxter AktiengesellschaftInventors: Heinz Redl, Guenther Schlag, Irmgard Schlag, legal representative, Johann Eibl
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Publication number: 20100292717Abstract: The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.Type: ApplicationFiled: May 18, 2009Publication date: November 18, 2010Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: ALEXANDER PETTER-PUCHNER, Heinz Redl
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Publication number: 20100203050Abstract: The present invention relates to recombinant fusion proteins wherein erythropoietin (EPO) is linked via its C-terminus to an Fc fragment, and wherein said recombinant fusion proteins are further carbamoylated at the primary amines of the fusion protein. More specifically the invention relates to carbamoylated EPO-Fc fusion proteins, wherein at least one, preferably two or more, lysine amine residues and/or the N-terminal amino acid of said fusion protein are carbamoylated. The carbamoylated EPO-Fc fusion proteins of the present invention having a reduced hematopoietic activity whereas the tissue regenerative activity, i.e. the nerval cell regenerative activity remains unaltered or is even enhanced as compared to unmodified EPO-Fc fusion proteins. The invention further relates to a process for the manufacture of such fusion proteins and to pharmaceutical compositions containing them, as well as to the use of such fusion proteins and pharmaceutical compositions for medical therapy.Type: ApplicationFiled: February 20, 2008Publication date: August 12, 2010Applicant: POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBHInventors: Robert Weik, Thomas Hemetsberger, Heinz Redl
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Publication number: 20100168779Abstract: A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly combined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube directs a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding excessive pressure build-up within a body cavity.Type: ApplicationFiled: December 30, 2009Publication date: July 1, 2010Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Heinz Redl, Zafar Khakpour, Rene Fortelny
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Publication number: 20090311240Abstract: The present application demonstrates the clinical potential of fibrin sealants to locally deliver growth factors to ischemic tissue. More particularly, it demonstrates that hydrogels such as Fibrin Sealants can be used to deliver VEGF165 to prevent tissue necrosis caused by hypoxia or ischemia. Specifically, a Fibrin Sealant (FS) was used to deliver VEGF165 to treat tissue necrosis in both a rodent dorsal flap model and a rodent epigastric flap model. Flaps treated with FS spiked with (rh)VEGF165 developed less necrotic tissue. In addition, immunohistological studies revealed a greater numbers of blood vessels (angiogenesis).Type: ApplicationFiled: May 22, 2009Publication date: December 17, 2009Applicants: Baxter International Inc., Baxter Healthcare S.A.Inventors: Rainer Mittermayr, Sam L. Helgerson, Heinz Redl
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Publication number: 20090275011Abstract: Sterile, virally safe, heterologous, homologous, isologous or autologous tissue, tissue-typed or not tissue-typed, which contains predifferentiated and/or differentiable sessile stem cells and which can be used for wound closure and/or promotion of wound healing.Type: ApplicationFiled: February 9, 2009Publication date: November 5, 2009Inventors: Johann Eibl, Heinz Redl
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Publication number: 20090152305Abstract: An applicator includes a bore for containing a sealant component, a piston moveably positioned in the bore, a plunger member connected to the piston with a distal end disposed within the bore and a proximal end depending from the bore, a distal outlet communicating with the bore and connectable to a gas source, and an actuating member carried by the proximal end of the plunger member to move with the plunger member as the plunger member moves along the bore. The applicator may be used in a system with a gas source connected to the distal outlet, and a control unit connected to the actuating member and the gas source, the control unit adapted to supply gas to the distal outlet from the gas source essentially simultaneous with a force applied to the actuating member.Type: ApplicationFiled: February 20, 2009Publication date: June 18, 2009Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Heinz Redl, Zafar Khakpour, Scott R. Ariagno, Andreas Kellner, Lillian G. Zakarija
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Patent number: 7537174Abstract: The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body defining an interior bore and having a piston movably positioned in the bore and a pusher member operatively associated with the piston. The assembly comprises a spray adaptor adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.Type: GrantFiled: January 12, 2006Date of Patent: May 26, 2009Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Heinz Redl, Zafar Khakpour, Scott R. Ariagno, Andreas Kellner, Lillian G. Zakarija
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Publication number: 20090041748Abstract: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.Type: ApplicationFiled: October 16, 2008Publication date: February 12, 2009Applicant: Baxter AktiengesellschaftInventors: Heinz Redl, Guenther Schlag, Irmgard Schlag, Johann Eibl
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Patent number: 7459295Abstract: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.Type: GrantFiled: May 30, 2006Date of Patent: December 2, 2008Assignee: Baxter AktiengesellschaftInventors: Heinz Redl, Gunther Schlag, Johann Eibl
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Patent number: 7326412Abstract: Reducing or preventing adhesions which would otherwise form in a patient during or after surgery by administering a fibrinogen preparation containing a non-plasmin-acting fibrinolysis inhibitor such as eglin.Type: GrantFiled: October 12, 2001Date of Patent: February 5, 2008Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Heinz Redl
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Patent number: 7198786Abstract: Reducing or preventing adhesions which would form in a patient during or after surgery by administering to the wound surface of a patient a fibrinogen solution in an amount of about 0.025 ml fibrinogen/cm2 to about 0.25 ml fibrinogen/cm2 of the surface being at risk for developing adhesions. User of fibrinogen in a preparation comprising fibrinogen at a concentration of 20 to 80 mg/ml for the reduction or prevention of post-surgical adhesion formation.Type: GrantFiled: October 12, 2001Date of Patent: April 3, 2007Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Heinz Redl, Reiner Spaethe, Manuela Simunek
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Publication number: 20060216280Abstract: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.Type: ApplicationFiled: May 30, 2006Publication date: September 28, 2006Applicant: Baxter AktiengesellschaftInventors: Heinz Redl, Guenther Schlag, Johann Eibl
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Publication number: 20060191962Abstract: The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body defining an interior bore and having a piston movably positioned in the bore and a pusher member operatively associated with the piston. The assembly comprises a spray adaptor adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.Type: ApplicationFiled: January 12, 2006Publication date: August 31, 2006Inventors: Heinz Redl, Zafar Khakpour, Scott Ariagno, Andreas Kellner, Lillian Zakarija
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Patent number: 7091015Abstract: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.Type: GrantFiled: August 26, 1998Date of Patent: August 15, 2006Assignee: Baxter AktiengesellschaftInventors: Heinz Redl, Guenther Schlag, Johann Eibl
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Patent number: 7091325Abstract: A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.Type: GrantFiled: December 30, 2003Date of Patent: August 15, 2006Assignees: Baxter Aktiengesellschaft, Baxter International Inc.Inventors: Heinz Redl, Walter Fuerst, Rudolf Kneidinger, Sam L. Helgerson, Douglas Looker, Elisabeth M. Inman, Jane P. Richards, Catalina Wong
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Publication number: 20060177812Abstract: The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (2) for punching holes (34) in sample carriers (4) and at least one further needle (3) for punching samples out of preparations (5), wherein a device for detecting the position of the surface of the sample carriers (4) is provided. According to the invention, the device for detecting the position of the surface of the sample carriers (4) or preparations (5) is formed by suction lines (9) opening into the needles (2, 3), whereby the suction lines (9) are connected with a unit (11) for detecting negative pressure so that the approach of the needles (2, 3) to the surface of the sample carriers (4) or the preparations (5) is detectable by the resulting negative pressure and that a drive unit (7) is provided for displacing the needles (2, 3) relative to the sample carrier (4) or preparation (5) from the detected position of the surface to a predefined punching depth (D).Type: ApplicationFiled: October 30, 2003Publication date: August 10, 2006Applicant: ORDIS BIOMED Forschungs- und Entwicklungs GmbHInventors: Guntram Schnetz, Heinz Redl, Kurt Zatloukal
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Publication number: 20060147896Abstract: The invention relates to a method and a device for manipulating samples, in particular tissue samples, with at least one needle (3) for punching samples from preparations (5), in particular prepared tissue specimen, at defined positions and a control device (13) to control the needle (3). The aim of the invention is to provide a method and a device, which allow a simple selection of desired punch positions on the preparation (5) and enable a rapid, simple and automatic manipulation of samples.Type: ApplicationFiled: October 30, 2003Publication date: July 6, 2006Applicant: ORIDIS BIOMED Forschungs-und Entwicklings GmbHInventors: Guntram Schnetz, Heinz Redl, Kurt Zatloukal