Patents by Inventor Heinz-Werner Kleemann

Heinz-Werner Kleemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted anthranilic acids, their use as a medicament or diagnostic, and medicament comprising them, and a pharmaceutical combination preparation containing a sodium/hydrogen exchange (NHE) blocker
    Publication number: 20020123632
    Abstract: Substituted anthranilic acids of the formula I 1
    Type: Application
    Filed: December 6, 2001
    Publication date: September 5, 2002
    Inventors: Andreas Weichert, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang, Hartmut Rutten
  • Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them
    Patent number: 6436999
    Abstract: Diacyl-substituted guanidines of the formula I are described where X(1) and X(2) are as defined herein. The compounds are suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventitive manner the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: August 20, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz-Werner Kleemann, Hans-Jochen Lang, Andreas Weichert, Peter Crause, Wolfgang Scholz, Udo Albus, Jan-Robert Schwark
  • Heterocyclically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them
    Publication number: 20020099222
    Abstract: Heterocyclically substituted benzoylguanidines of the formula I 1
    Type: Application
    Filed: February 15, 2002
    Publication date: July 25, 2002
    Inventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang
  • Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Publication number: 20020045761
    Abstract: Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them.
    Type: Application
    Filed: October 30, 2001
    Publication date: April 18, 2002
    Inventors: Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Sabine Faber, Hans-Willi Jansen
  • Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
    Patent number: 6372917
    Abstract: The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: April 16, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Stefan Petry
  • Imidazole derivatives with biphenylsulfonyl substitution method for preparing them and their use as a drug or diagnostic agent
    Patent number: 6369236
    Abstract: The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: April 9, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Stefan Petry, Andreas Weichert
  • Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament
    Patent number: 6369069
    Abstract: The invention relates to compounds of the formula (I), in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine; 3. alkenyl having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; or 4. —CnH2n−nn—Y, nn is zero or 2; and n is zero, 1, 2, 3 or 4; where n is unequal to zero or 1 if nn is equal to 2; 5. —CnH2n−nn—Y, nn is zero or 2; and n is 1, 2, 3 or 4; where n is unequal to 1 if nn is equal to 2.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: April 9, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Hans-Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Sabine Faber, Hans-Willi Jansen, Stefan Petry
  • Substituted 4-benzylaminoquinolines and their hetero analogs, process for their preparation, pharmaceuticals containing these compounds and use thereof
    Patent number: 6339077
    Abstract: The invention relates to substituted 4-benzylaminoquinolines and their hetero analogs, and to the pharmaceutically acceptable salts and physiologically functional derivatives thereof. Compounds of formula I in which the radicals are defined in the specification, and their physiologically tolerated salts, physiologically functional derivatives and processes for their preparation are described. The compounds are suitable, for example, as medicines for the prophylaxis or treatment of gallstones.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: January 15, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Armin Hofmeister, Eugen Falk, Heinz-Werner Kleemann, Hans-Willi Jansen, Martin Bickel
  • Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them
    Patent number: 6335451
    Abstract: Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I in which the symbols have the meanings indicated in the claims, have outstanding antiarrhythmic properties and exhibit a cardioprotective component. They can preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a potent inhibitory action on the proliferation of cells.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: January 1, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Sabine Faber, Hans-Willi Jansen
  • Heterocyclically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them
    Publication number: 20010049446
    Abstract: Heterocyclically substituted benzoylguanidines of the formula I 1
    Type: Application
    Filed: July 11, 2001
    Publication date: December 6, 2001
    Inventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans-Jochen Lang
  • Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them
    Publication number: 20010023257
    Abstract: The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them
    Type: Application
    Filed: December 12, 2000
    Publication date: September 20, 2001
    Inventors: Uwe Heinelt, Hans-Jochen Lang, Heinz-Werner Kleemann, Jan-Robert Schwark, Klaus Wirth, Hans-Willi Jansen
  • Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
    Publication number: 20010020042
    Abstract: This invention relates to fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them.
    Type: Application
    Filed: February 8, 2001
    Publication date: September 6, 2001
    Applicant: Hoechst Aktiengesellschaft
    Inventors: Jan-Robert Schwark, Hans-Jochen Lang, Heinz-Werner Kleemann, Andreas Weichert, Wolfgang Scholz, Udo Albus
  • Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
    Publication number: 20010016596
    Abstract: Benzoylguanidines of the formula (I) 1
    Type: Application
    Filed: January 17, 2001
    Publication date: August 23, 2001
    Applicant: Aventis Pharma Deutschland GmbH.
    Inventors: Andreas Weichert, Udo Albus, Hans-Willi Jansen, Heinz-Werner Kleemann, Hans Jochen Lang
  • Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6262123
    Abstract: Ortho-substituted benzoylguanidines of the formula I in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: July 17, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Udo Albus, Joachim Brendel, Heinz-Werner Kleemann, Hans Jochen Lang, Wolfgang Scholz, Jan-Robert Schwark, Andreas Weichert
  • 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
    Patent number: 6156800
    Abstract: There are described benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO.sub.m, R(5)R(6)N--SO.sub.2 --; O.sub.p --(CH.sub.2).sub.q --(CF.sub.2).sub.r --CF.sub.3 ; --SR(10), --OR(10) or --CR(10)R(11)R(12); R(2) is --(CH.sub.2).sub.u --(CF.sub.2).sub.t --CF.sub.3 ; R(3) is hydrogen or independently defined as R(1); and their pharmaceutically tolerable salts. They are obtained by reaction of a compound of the formula II ##STR2## with guanidine. They are compounds of outstanding activity on the cardiovascular system.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: December 5, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Andreas Weichert, Joachim Brendel, Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Wolfgang Scholz, Udo Albus
  • Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6153651
    Abstract: Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them.Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: November 28, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Udo Albus, Joachim Brendel, Heinz-Werner Kleemann, Hans Jochen Lang, Wolfgang Scholz, Jan-Robert Schwark, Andreas Weichert
  • Substituted bicyclic heteroaroylguanidines, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them
    Patent number: 6093729
    Abstract: Substituted bicyclic heteroaroylguanidines, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them are described, as are the pharmaceutically tolerated salts thereof. A process for their preparation, and their use as medicines and diagnostic aids in cardiovascular diseases, is also described.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: July 25, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jan-Robert Schwark, Heinz-Werner Kleemann, Hans-Jochen Lang, Andreas Weichert, Wolfgang Scholz, Udo Albus
  • Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
    Patent number: 6087304
    Abstract: Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing themSubstituted 2-naphthoylguanidines of the formula I ##STR1## having the meanings indicated in claim 1 for R1 to R8, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: July 11, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Joachim Brendel, Heinz-Werner Kleemann, Heinrich Christian Englert, Hans Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Bansi Lal
  • Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6075054
    Abstract: Benzoylguanidines of formula I ##STR1## with R(1) to R(4) as defined in the specification, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris.They inhibit, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Andreas Weichert, Joachim Brendel, Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Udo Albus, Wolfgang Scholz
  • Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them
    Patent number: 6057322
    Abstract: Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also described.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: May 2, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz-Werner Kleemann, Hans-Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Wolfgang Scholz, Udo Albus