Abstract: The invention is in the field of molecular diagnosis of medical diseases and their treatment. More in particular, it provides methods and means for detecting hypertension, more in particular essential primary hypertension, even more in particular NOX5-dependent hypertension. The invention also provides methods for the treatment of hypertension, in particular essential primary hypertension, more in particular NOX5-dependent hypertension. The invention also provides theragnostics, wherein therapy is combined with diagnosis, more in particular wherein the level of NOX5 is determined in a sample from a subject and wherein the subject is treated with NOX5 inhibitors or compounds that decrease the levels of NOX5 if the NOX5 levels are above a certain threshold value.

Abstract: The invention relates to a pharmaceutical composition comprising one or more stimulators of soluble guanylate cyclase (sGC), or a combination of at least one stimulator of sGC and at least one activator of sGC, for use in a method of treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3?,5?-guanosine monophosphate in the patient to be treated. The invention also relates to a therapeutic combination comprising a first unit dose comprising an sGC stimulator and a second unit dose comprising an sGC activator. The invention also relates to a therapeutic combination comprising a first unit dose comprising a first sGC stimulator and a second unit dose comprising a second sGC stimulator, for use in a method for the treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3?,5?-guanosine monophosphate in the patient to be treated.

Abstract: The present invention relates to a therapeutic combination comprising two or three of at least one NADPH oxidase inhibitor, at least one nitric oxide synthase inhibitor and at least one soluble guanylate cyclase agonist. More specifically, the invention relates to said therapeutic combination for use in the prevention or treatment of brain ischemia or for use in the prevention or treatment of ischemia-reperfusion injury. The invention also relates to a pharmaceutical composition comprising two or three of at least one NADPH oxidase inhibitor, at least one nitric oxide synthase inhibitor and at least one soluble guanylate cyclase agonist, and to said pharmaceutical composition for use in the prevention or treatment of brain ischemia or for use in the prevention or treatment of ischemia-reperfusion injury.

Abstract: The invention is in the field of molecular diagnosis of medical diseases and their treatment. More in particular, it provides methods and means for detecting hypertension, more in particular essential primary hypertension, even more in particular NOX5-dependent hypertension. The invention also provides methods for the treatment of hypertension, in particular essential primary hypertension, more in particular NOX5-dependent hypertension. The invention also provides theragnostics, wherein therapy is combined with diagnosis, more in particular wherein the level of NOX5 is determined in a sample from a subject and wherein the subject is treated with NOX5 inhibitors or compounds that decrease the levels of NOX5 if the NOX5 levels are above a certain threshold value.

Abstract: This invention relates to a damping device for mounting two separate components for damping oscillations between the components, wherein the damping device has an axial damper that comprises a first connecting element as well as a second connecting element, wherein the first connecting element is connected to the second connecting element via a damping section by ensuring an axial relative movement of the two connecting elements with respect to one another, wherein the damping section is designed for damping the axial relative movement between the connecting elements.

Abstract: The invention relates to a valve to ensure pressure compensation between subchambers of a hydraulic damper, wherein the valve comprises a first side for connection to a first subchamber and a second side for connection to a second subchamber, the valve is designed to shut off in its rest position a flow of fluid between the two sides and comprises, when deflected from its rest position, a passage channel with a passage cross-section for admitting the flow of fluid, the valve comprises two valve elements guided towards each other and movable towards each other along a path of movement in a movement direction x, one of the two valve elements is designed as a moving element and the other valve element as a seat element, a pressure can be applied to the moving element, on the load side thereof, by a fluid coming from the first side, generating an effective force for moving the moving element in the moving direction x, and the moving element is connected to a spring system which applies to the moving element a spr

Abstract: Provided is a signal isolator with reduced power loss. The signal isolating circuit comprises an input stage and an output circuit that is connected downstream thereof and which includes a linear regulator. The linear regulator comprises an operational amplifier and a switching regulator, wherein an input of the switching regulator is connected to an output of the operational amplifier and an output of the switching regulator is fed back to a first input of the operational amplifier. The operational amplifier regulates the switching regulator such that the switching regulator provides at its output an output measuring signal for a load that corresponds to the input measuring signal.

Abstract: The invention relates to a current output stage (100) comprising an input (IN), an output (OUT) for connecting to an input of a unit (200) to be supplied with current, a control stage (T1, T2, Z1), which sets the output current (Iout), and an energy supply stage (Uv;Uv,?Uv), which can provide energy for the output current (Iout). The current output stage (100) comprises a first transistor (T1), which controls the output current in a closed-loop in the passive operating mode, and the current output stage (100) contains a second transistor (T2; T2, T3), which controls the output current (Iout) in a closed-loop in the active operating mode, wherein the first transistor (T1) and the second transistor (T2; T2, T3) is controlled by a control stage OP1) in an open loop, and wherein in the active operating mode the energy supply stage (Uv;Uv,?Uv) is controlled in an open loop such that same provides energy for the output current (Iout).

Abstract: This invention relates to a damping device for mounting two separate components for damping oscillations between the components, wherein the damping device has an axial damper that comprises a first connecting element as well as a second connecting element, wherein the first connecting element is connected to the second connecting element via a damping section by ensuring an axial relative movement of the two connecting elements with respect to one another, wherein the damping section is designed for damping the axial relative movement between the connecting elements.

Abstract: The invention relates to a valve to ensure pressure compensation between subchambers of a hydraulic damper, wherein the valve comprises a first side for connection to a first subchamber and a second side for connection to a second subchamber, the valve is designed to shut off in its rest position a flow of fluid between the two sides and comprises, when deflected from its rest position, a passage channel with a passage cross-section for admitting the flow of fluid, the valve comprises two valve elements guided towards each other and movable towards each other along a path of movement in a movement direction x, one of the two valve elements is designed as a moving element and the other valve element as a seat element, a pressure can be applied to the moving element, on the load side thereof, by a fluid coming from the first side, generating an effective force for moving the moving element in the moving direction x, and the moving element is connected to a spring system which applies to the moving element a spr

Abstract: Provided is a signal isolator with reduced power loss. The signal isolating circuit comprises an input stage and an output circuit that is connected downstream thereof and which includes a linear regulator. The linear regulator comprises an operational amplifier and a switching regulator, wherein an input of the switching regulator is connected to an output of the operational amplifier and an output of the switching regulator is fed back to a first input of the operational amplifier. The operational amplifier regulates the switching regulator such that the switching regulator provides at its output an output measuring signal for a load that corresponds to the input measuring signal.

Abstract: The use is described of at least one succinate dehydrogenase (SDH) inhibitor for increasing the biomass of the flag leaf, of leaf F-1 and/or of leaf F-2 of the plant of plant species from the family of the true grasses (Poaceae).

Abstract: The invention relates to a current output stage (100) comprising an input (IN), an output (OUT) for connecting to an input of a unit (200) to be supplied with current, a control stage (T1, T2, Z1), which sets the output current (Iout), and an energy supply stage (Uv;Uv,?Uv), which can provide energy for the output current (Iout). The current output stage (100) comprises a first transistor (T1), which controls the output current in a closed-loop in the passive operating mode, and the current output stage (100) contains a second transistor (T2; T2, T3), which controls the output current (Iout) in a closed-loop in the active operating mode, wherein the first transistor (T1) and the second transistor (T2; T2, T3) is controlled by a control stage OP1) in an open loop, and wherein in the active operating mode the energy supply stage (Uv;Uv,?Uv) is controlled in an open loop such that same provides energy for the output current (Iout).

Abstract: The present invention provides a composition comprising synergistic amounts of a compound of the formula (I) wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active compound as defined herein. The compositions of the present invention find use as pesticides.

Abstract: A constant bearer having a fastening part, a load-bearing part and a spring system which is arranged between the fastening part and the load-bearing part for generating a carrying force which remains constant over a carrying travel of the load-bearing part with respect to the fastening part, where the spring system has a suspension system for absorbing the load, a compensation device for compensating for changing spring forces of the suspension system over the carrying travel, and a prestressing device for setting a prestressing force of the suspension system.

Abstract: A fire-resistant laminated glazing comprising at least two glazing panes and at least one transparent intumescent interlayer between the glazing panes, said glazing panes being separated by a spacer extending at least partially around their peripheries so as to define a cavity to contain said interlayer, wherein the spacer comprises a shim for controlling the separation between the glazing panes to a predetermined distance and a rubber portion at least partially enclosing the shim, and wherein the interlayer comprises an alkali metal silicate.

Abstract: Novel pyridyl cyanoguanidine compounds of general formula I (I) wherein R1, X, R2 and R3 are as defined herein, exhibit a high antiproliferative activity and may be used in the treatment of hyperproliferative and neo-plastic diseases.

Abstract: The use is described of at least one succinate dehydrogenase (SDH) inhibitor for increasing the biomass of the flag leaf, of leaf F-1 and/or of leaf F-2 of the plant of plant species from the family of the true grasses (Poaceae).

Abstract: The present invention provides a composition comprising imidacloprid and metalaxyl. The compositions of the present invention find use as pesticides.

Abstract: The present invention provides a composition comprising synergistic amounts of a compound of the formula (I) wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active compound as defined herein. The compositions of the present invention find use as pesticides.