Abstract: A method generates an alphanumeric or numeric key linked to personal genomic data. In a first step genomic data from a single genome are analyzed. Genetic markers are retrieved from the data and associated with various informations like, but not exclusively, their name, identification number, polymorphism frequency distribution in various populations, and localization in genome regions. Groups of genetic markers are then created according one or a combination of these informations. For each group, an alphanumeric or numeric value is computed and represent an element of the key. The assembly of each element produces the final key, named the “Genumber”. The Genumber can then be used securely in various applications to produce personalized results, linked to the genome source, like creative and artistic applications or secured transaction-based application like banking transactions or medical data storage, but not exclusively.