Patents by Inventor Helen Bignell

Helen Bignell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 11634768
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: April 25, 2023
    Assignee: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • DETECTION OF EPIGENETIC MODIFICATIONS
    Publication number: 20230102739
    Abstract: Provided herein are systems and methods for detection of an epigenetic modification in a nucleic acid sequence. The systems and methods as described herein may provide a substantially unbiased approach in detecting an epigenetic modification. The systems and method as described herein may provide a substantially unbiased approach in detecting an epigenetic modification in comparison to systems and methods that amplify sequences having a label or a moiety associated with an epigenetic modification.
    Type: Application
    Filed: May 15, 2018
    Publication date: March 30, 2023
    Inventors: Michael Steward, Tobias Ost, Shirong Yu, Helen Bignell
  • METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES
    Publication number: 20210292810
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 23, 2021
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 10988806
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 27, 2021
    Assignee: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES
    Publication number: 20200080145
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: June 21, 2019
    Publication date: March 12, 2020
    Applicant: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 10457985
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: October 29, 2019
    Assignee: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES
    Publication number: 20170145499
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: November 30, 2016
    Publication date: May 25, 2017
    Applicant: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 9512478
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: December 6, 2016
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES
    Publication number: 20140329698
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: June 17, 2014
    Publication date: November 6, 2014
    Applicant: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 8822150
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: September 2, 2014
    Assignee: Illumina Cambridge Limited
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Publication number: 20120316072
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: April 11, 2012
    Publication date: December 13, 2012
    Applicant: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 8182989
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: May 22, 2012
    Assignee: Illumina Cambridge Ltd.
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Publication number: 20120015823
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: August 18, 2011
    Publication date: January 19, 2012
    Applicant: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Patent number: 8053192
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: November 8, 2011
    Assignee: Illumina Cambridge Ltd.
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Methods for indexing samples and sequencing multiple polynucleotide templates
    Publication number: 20090233802
    Abstract: The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.
    Type: Application
    Filed: February 4, 2008
    Publication date: September 17, 2009
    Inventors: Helen Bignell, Louise Fraser, Niall Anthony Gormley
  • Method for sequencing a polynucleotide template
    Publication number: 20090093378
    Abstract: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.
    Type: Application
    Filed: August 28, 2008
    Publication date: April 9, 2009
    Inventors: Helen Bignell, Niall Anthony Gormley, Matthew Hims, Geoffrey Smith, John Stephen West