Abstract: Systems and methods for digitographic measurement of Parkinson's disease in accordance with embodiments of the invention are illustrated. One embodiment includes a digitographic measurement device, including a housing, a plurality of keys attached to the housing, a plurality of sensors, sensor in the plurality of sensors is associated with a key in the plurality of keys and is capable of measuring the amplitude of a key press, and an input/output interface within the housing, where the digitographic measurement device is configured to transmit key press data generated by the sensors to a controller via the input/output interface, and where the key press data is used to generate a plurality of digitographic metrics that describe motor symptoms of a user of the digitographic measurement device.

Abstract: Systems and methods for deep brain stimulation using kinematic feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including an implantable neurostimulator, a first inertial measurement unit (IMU), a second IMU, and a controller, where the controller is communicatively coupled to the implantable neurostimulator, the first IMU, and the second IMU, and where the controller is configured to obtain kinematic data from the first IMU and the second IMU, identify an abnormal movement event based on the kinematic data, and modify deep brain stimulation provided by the implantable neurostimulator based on the identified abnormal movement event.

Abstract: Systems and methods for deep brain stimulation using beta burst feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including a neurostimulator, and a controller, where the controller is communicatively coupled to the neurostimulator and configured to obtain a plurality of neural activity signals from the neurostimulator, identify beta bursts within each neural activity signal, classify identified beta bursts as pathological or normal, and modify stimulation provided by the neurostimulator based on the classified beta bursts.