Patents by Inventor Helen Burgwyn FUCHS

Helen Burgwyn FUCHS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial and antifungal compounds
    Patent number: 11707442
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 25, 2023
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn Fuchs, Eleftherios Mylonakis, Frederick M. Ausubel, Raj Mohan Raja Muthiah, Wooseong Kim
  • Probiotic bacteria-directed prevention or treatment of fungal infection
    Patent number: 11478516
    Abstract: The invention provides a method and bacterial compositions for reducing or preventing an infection of a bodily tissue by a fungal microorganism by contacting the tissue with a composition comprising a purified Lactobacillus paracasei bacterium.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 25, 2022
    Assignees: RHODE ISLAND HOSPITAL, UNIVERSIDADE ESTADUAL PAULISTA/UNESP
    Inventors: Juliana Campos Junqueira, Helen Burgwyn Fuchs, Eleftherios Mylonakis
  • PROBIOTIC BACTERIA-DIRECTED PREVENTION OR TREATMENT OF FUNGAL INFECTION
    Publication number: 20190151382
    Abstract: The invention provides a method and bacterial compositions for reducing or preventing an infection of a bodily tissue by a fungal microorganism by contacting the tissue with a composition comprising a purified Lactobacillus paracasei bacterium.
    Type: Application
    Filed: July 31, 2017
    Publication date: May 23, 2019
    Inventors: Juliana Campos Junqueira, Helen Burgwyn Fuchs, Eleftherios Mylonakis
  • ANTIBACTERIAL AND ANTIFUNGAL COMPOUNDS
    Publication number: 20190054048
    Abstract: The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. faecalis, E. faecium, B. subtilis, and B. anthracis. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as Sa bacterial infection caused by S. aureus, methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), E. spp., K. pneumoniae, P. aeruginosa, A. baumannii, E. faecium, and E. faecalis. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. neoformans.
    Type: Application
    Filed: September 23, 2016
    Publication date: February 21, 2019
    Applicants: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner
    Inventors: Helen Burgwyn FUCHS, Eleftherios MYLONAKIS, Frederick M. AUSUBEL, Raj Mohan Raja MUTHIAH, Wooseong KIM