Patents by Inventor Helen C. Loughrey

Helen C. Loughrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for protein-liposome coupling
    Patent number: 5399331
    Abstract: This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subsequently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: March 21, 1995
    Assignee: The Liposome Company, Inc.
    Inventors: Helen C. Loughrey, Pieter R. Cullis, Marcel B. Bally, Lewis S. Choi
  • Preparation of targeted liposome systems of a defined size distribution
    Patent number: 5059421
    Abstract: The present invention relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm.The liposomes of the invention may have a transmembrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineplastic agents, and may be used in diagnostic assays.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: October 22, 1991
    Assignee: The Liposome Company, Inc.
    Inventors: Helen C. Loughrey, Pieter R. Cullis, Marcel B. Bally, Lewis S. L. Choi, Kim F. Wong