Patents by Inventor Helen H. Lu

Helen H. Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIODEGRADABLE TEXTILE FIBERS WITH INHERENT COLOR AND PROPERTIES
    Publication number: 20230322902
    Abstract: A biopolymer composition can be formed based, at least in part, on a recombinantly expressed protein, expressed from a DNA coding sequence of a source protein, and the recombinantly expressed protein can optionally comprise one or more tags that enhance the crosslinking capacity of the protein. It was determined that such biopolymer composition can be suitable for use to obtain, for example, a biodegradable textile that exhibits a functional characteristic associated with the recombinantly expressed protein.
    Type: Application
    Filed: March 24, 2021
    Publication date: October 12, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Theanne Schiros, Chui Lian Lee, Valentina Gomez, Morgana Katterm, Helen H. Lu, Alie Obermeyer, Philip Brudnicki, Sebastian S. Cocioba, Christopher Z. Mosher, Romare M. Antrobus, Yuncan Zuh, Aditi Sharma
  • BIOFABRICATION AND MICROBIAL CELLULOSE BIOTEXTILE
    Publication number: 20230146427
    Abstract: A biomaterial may be produced by employing bacterial nanocellulose which are biologically functional and can be enhanced via an enzyme tanning treatment, to form a functional biotextile that has improved functionality and various desirable and/or enhanced properties.
    Type: Application
    Filed: January 14, 2021
    Publication date: May 11, 2023
    Inventors: Theanne SCHIROS, Helen H. LU, Romare M. ANTROBUS, Christan JOSEPH, Adrian M. CHITU, Shanece ESDAILLE, Susanne GOETZ, Anne VERPLOEGH CHASSÉ, ESPOSITO DANIELLA, Arianna WONG, Dylon SHEPELSKY
  • FIBROUS POLYMERIC SCAFFOLDS FOR SOFT TISSUE ENGINEERING
    Publication number: 20220331490
    Abstract: A fibrous polymeric scaffold for soft tissue engineering comprises electrospun fibers including a polymeric blend and graphite particles embedded therein.
    Type: Application
    Filed: February 9, 2022
    Publication date: October 20, 2022
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Christopher Z. Mosher, Romare Antrobus, James C. Hone, Theanne Schiros, Yilin Yang
  • Methods for host cell homing and dental pulp regeneration
    Patent number: 11110199
    Abstract: Hydrogel-based scaffolds useful for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both as well as methods for their production and use are provided.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Helen H. Lu, Sagaw Prateepchinda, Gunnar Hasselgren
  • METHODS FOR HOST CELL HOMING AND DENTAL PULP REGENERATION
    Publication number: 20190209734
    Abstract: Hydrogel-based scaffolds useful for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both as well as methods for their production and use are provided.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventors: Helen H. LU, Sagaw PRATEEPCHINDA, Gunnar HASSELGREN, Dror SELIKTAR
  • Methods, compositions, and systems for activation and expansion of cells
    Patent number: 10301590
    Abstract: The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 28, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Lance C. Kam, Helen H. Lu, Sarah E. De Leo, Keenan T. Bashour, Danielle Bogdanowicz, Philip Chuang
  • Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
    Patent number: 10265155
    Abstract: An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: April 23, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kristen L. Moffat, William N. Levine
  • Methods, Compositions, and Systems for Activation and Expansion of Cells
    Publication number: 20170029767
    Abstract: The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
    Type: Application
    Filed: April 10, 2015
    Publication date: February 2, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Lance C. KAM, Helen H. LU, Sarah E. DE LEO, Keenan T. BASHOUR, Danielle BOGDANOWICZ, Philip CHUANG
  • METHODS FOR HOST CELL HOMING AND DENTAL PULP REGENERATION
    Publication number: 20160296664
    Abstract: Hydrogel-based scaffolds useful for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both as well as methods for their production and use are provided.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 13, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Helen H. LU, Sagaw PRATEEPCHINDA, Gunnar B HASSELGREN, Dror SELIKTAR
  • Multi-phased, biodegradable and oesteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
    Patent number: 9427495
    Abstract: Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: August 30, 2016
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kathie Kionisio
  • SCAFFOLDS FOR PROMOTING CALCIFIED CARTILAGE AND/OR BONE FORMATION
    Publication number: 20160058912
    Abstract: Biomimetic hydrogel and selected ceramic interface scaffolds useful in regenerating calcified cartilage and promoting stable and integrative cartilage repair are provided. An aspect of this application relates to scaffolds for promoting calcified cartilage and/or bone formation. The scaffolds of this application comprise a biomimetic hydrogel and a ceramic structure or mineral source selected to modulate biosynthesis and mineralization of chondrocytes.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. LU, Margaret K BOUSHELL
  • LIGAMENT AND TENDON REPLACEMENT CONSTRUCTS AND METHODS FOR PRODUCTION AND USE THEREOF
    Publication number: 20150190222
    Abstract: Degradable/polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 9, 2015
    Inventors: CATO T. LAURENCIN, FRANK K. KO, JAMES ARTHUR COOPER, JR., HELEN H. LU, MOHAMED A. ATTAWIA
  • BIOMIMMETIC NANOFIBER SCAFFOLD FOR SOFT TISSUE AND SOFT TISSUE-TO-BONE REPAIR, AUGMENTATION AND REPLACEMENT
    Publication number: 20150100121
    Abstract: An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 9, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kristen L. Moffat, William N. Levine
  • Ligament and tendon replacement constructs and methods for production and use thereof
    Patent number: 8945218
    Abstract: Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: February 3, 2015
    Assignee: Drexel University
    Inventors: Cato T. Laurencin, Frank K. Ko, James A. Cooper, Helen H. Lu, Mohammed A. Attawia
  • MULTI-PHASED, BIODEGRADABLE AND OESTEOINTEGRATIVE COMPOSITE SCAFFOLD FOR BIOLOGICAL FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE
    Publication number: 20150024063
    Abstract: Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
    Type: Application
    Filed: August 4, 2014
    Publication date: January 22, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kathie Kionisio
  • Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
    Patent number: 8864843
    Abstract: An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: October 21, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Kristen L. Moffat, William N. Levine
  • Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone
    Patent number: 8802122
    Abstract: Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: August 12, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kathie Dionisio
  • Fully synthetic implantable multi-phased scaffold
    Patent number: 8753391
    Abstract: An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: June 17, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Jeffrey Spalazzi
  • Methods for Producing Tissue Scaffold Directing Differentiation of Seeded Cells and Tissue Scaffolds Produced Thereby
    Publication number: 20130316454
    Abstract: Methods for producing a tissue scaffold which direct differentiation of seeded stem cells on the scaffold to a selected cell type and tissue scaffolds produced thereby are provided.
    Type: Application
    Filed: June 22, 2011
    Publication date: November 28, 2013
    Inventors: Helen H. Lu, Shang-pin Kwei, Natalie L. Leong, Marissa R. Solomon, Siddarth D. Subramony
  • Tissue Scaffolds for Controlled Release of Active Agents
    Publication number: 20130280318
    Abstract: Tissue scaffolds of polymer microfiber or nanofiber mesh which release an active agent supportive of alignment, proliferation and matrix deposition of selected musculoskeletal cell over time are provided. Methods for production and use of these tissue scaffolds in treatment of musculoskeletal tissue injuries are also provided.
    Type: Application
    Filed: July 12, 2011
    Publication date: October 24, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Cevat Erisken