Patents by Inventor Helen Horton

Helen Horton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B virus (HBV) vaccines and uses thereof
    Patent number: 11725194
    Abstract: Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: August 15, 2023
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy
  • Hepatitis B Virus (HBV) Vaccines and Uses Thereof
    Publication number: 20220324916
    Abstract: Polynucleotides encoding hepatitis B virus (HBV) surface antigens, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV surface antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 13, 2022
    Inventors: Helen Horton, Daniel Boden
  • SELF-REPLICATING RNA MOLECULES FOR HEPATITIS B VIRUS (HBV) VACCINES AND USES THEREOF
    Publication number: 20220313815
    Abstract: Self-replicating RNA molecules encoding hepatitis B virus (HBV) vaccines are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed self-replicating RNA molecules are also described. Kits comprising the disclosed self-replicating RNA molecules are also described.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 6, 2022
    Inventors: Helen HORTON, Daniel BODEN
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND SMALL MOLECULE PDL1 OR PD1 INHIBITOR
    Publication number: 20220305114
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and a small molecule PDL1 or PD1 inhibitor are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described. Kits comprising the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, Ellen Rosalie A. VAN GULCK, David Craig MC GOWAN
  • CARBOHYDRATE NANOCARRIER DELIVERY OF HEPATITIS B VIRUS (HBV) VACCINES
    Publication number: 20220305118
    Abstract: Pharmaceutical compositions containing hepatitis B virus (HBV) vaccines and carbohydrate polymers are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed pharmaceutical compositions are also described.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, Ian STRICKLAND, Daniel BODEN
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND CAPSID ASSEMBLY MODULATORS BEING SULFONAMIDE DERIVATIVES
    Publication number: 20220305116
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and a capsid assembly modulator are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, Jan BERKE, Frederik PAUWELS
  • LIPID NANOPARTICLE OR LIPOSOME DELIVERY OF HEPATITIS B VIRUS (HBV) VACCINES
    Publication number: 20220305108
    Abstract: Pharmaceutical compositions containing hepatitis B virus (HBV) vaccines and lipids are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed pharmaceutical compositions are also described.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, Ian STRICKLAND, Daniel BODEN
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAI
    Publication number: 20220305117
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an RNAi agent for inhibiting the expression of an HBV gene are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, An DE CREUS, Jan BERKE
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
    Publication number: 20220305107
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an RNAi agent for inhibiting the expression of an HBV gene are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, An Martine M. DE CREUS, Jan Martin BERKE
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES
    Publication number: 20220305115
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and a pyridopyrimidine derivative are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described. The invention provides therapeutic combinations or compositions and methods for inducing an immune response against hepatitis B viruses (HBV) infection.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Helen HORTON, Antony Chien-Hung CHEN
  • COBMINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND ANTI-PD-1 OR ANTI-PD-L1 ANTIBODY
    Publication number: 20220296703
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an anti-PD-1 or anti-PD-L1 antibody or antigen-binding fragment thereof are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 22, 2022
    Inventors: Helen HORTON, An Martine M. DE CREUS, Ellen Rosalie A. VAN GULCK
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND DIHYDROPYRIMIDINE DERIVATIVES AS CAPSID ASSEMBLY MODULATORS
    Publication number: 20220249647
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and capsid assembly modulators are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: August 11, 2022
    Inventors: Helen HORTON, Jan Martin BERKE, Frederik PAUWELS
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND QUINAZOLINE DERIVATIVES
    Publication number: 20220241402
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and quinazoline derivatives are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described. The invention provides therapeutic combinations or compositions and methods for inducing an immune response against hepatitis B viruses (HBV) infection.
    Type: Application
    Filed: June 18, 2020
    Publication date: August 4, 2022
    Inventors: Helen HORTON, Antony CHEN, David Craig MC GOWAN
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND DIHYDROPYRIMIDINE DERIVATIVES AS CAPSID ASSEMBLY MODULATORS
    Publication number: 20220233526
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and capsid assembly modulators are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: July 28, 2022
    Inventors: Helen HORTON, Jan Martin BERKE, Frederik PAUWELS
  • COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND ANTI-PD-1 ANTIBODY
    Publication number: 20220233685
    Abstract: Therapeutic combinations of hepatitis B virus (HBV) vaccines and an anti-PD-1 antibody or antigen-binding fragment thereof are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: July 28, 2022
    Inventors: Helen HORTON, An Martine M. DE CREUS, Ellen Rosalie A. VAN GULCK
  • ARENAVIRUS VECTORS FOR HEPATITIS B VIRUS (HBV) VACCINES AND USES THEREOF
    Publication number: 20220226467
    Abstract: Arenavirus vectors encoding hepatitis B virus (HBV) vaccines are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed arenavirus vectors are also described.
    Type: Application
    Filed: June 18, 2020
    Publication date: July 21, 2022
    Inventors: Helen HORTON, Daniel BODEN
  • Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
    Patent number: 11389531
    Abstract: Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: July 19, 2022
    Assignees: Janssen Sciences Ireland Unlimited Company, Ichor Medical Systems, Inc.
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy, Andrew W. Hannaman, Robert M. Bernard, Stephen A. Morse, Oliver Ruck, Adam Hartman, Thomas David Cox, Dorien De Pooter
  • Methods and Compositions for Inducing an Immune Response Against Hepatitis B Virus (HBV)
    Publication number: 20210268104
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Application
    Filed: May 18, 2021
    Publication date: September 2, 2021
    Inventors: Daniel BODEN, Helen HORTON, Jean-Marc Edmond Fernand Marie NEEFS, Soumitra ROY, Jerôme Hubertina Henricus Victor CUSTERS, Roland Christian ZAHN, Markus KALLA
  • HEPATITIS B VIRUS (HBV) VACCINES AND USES THEREOF
    Publication number: 20210269778
    Abstract: Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 2, 2021
    Inventors: Daniel BODEN, Helen HORTON, Jean-Marc Edmond Fernand Marie NEEFS, Soumitra ROY
  • Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
    Patent number: 11020476
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 1, 2021
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy, Jerôme Hubertina Henricus Victor Custers, Roland Christian Zahn, Markus Kalla