Patents by Inventor Helen Moinova

Helen Moinova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20240068045
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
    Type: Application
    Filed: October 19, 2023
    Publication date: February 29, 2024
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Amitabh Chak
  • METHODS OF DETECTING HIGH RISK BARRETT'S ESOPHAGUS WITH DYSPLASIA, AND ESOPHAGEAL ADENOCARCINOMA
    Publication number: 20240068033
    Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.
    Type: Application
    Filed: January 14, 2022
    Publication date: February 29, 2024
    Inventors: Sanford Markowitz, Amitabh Chak, Helen Moinova, Joseph Willis, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettewgowda, Christopher Douville
  • COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
    Publication number: 20220243281
    Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
    Type: Application
    Filed: May 28, 2020
    Publication date: August 4, 2022
    Inventors: Sanford D. Markowitz, Helen Moinova, David Wurtman
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20220154294
    Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
    Type: Application
    Filed: February 2, 2022
    Publication date: May 19, 2022
    Inventors: Sanford D. Markowitz, Helen Moinova, Amitabh Chak, Joseph Willis, Thomas LaFramboise
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20190309372
    Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
    Type: Application
    Filed: July 5, 2017
    Publication date: October 10, 2019
    Inventors: Sanford D. Markowitz, Helen Moinova, Amitabh Chak, Joseph Willis, Thomas LaFramboise
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20190136325
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially/methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
    Type: Application
    Filed: December 30, 2015
    Publication date: May 9, 2019
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Amitabh Chak
  • METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS
    Publication number: 20170369948
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 28, 2017
    Applicant: Case Western Reserve University
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Ryan Fecteau
  • ABERRANT METHYLATION OF C6ORF150 DNA SEQUENCES IN HUMAN COLORECTAL CANCER
    Publication number: 20140113290
    Abstract: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.
    Type: Application
    Filed: December 17, 2013
    Publication date: April 24, 2014
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, CASE WESTERN RESERVE UNIVERSITY
    Inventors: Sanford D. Markowitz, Helen Moinova, Lois Myeroff, Jean-Pierre Issa, Osamu Maeda
  • Aberrant methylation of C6Orf150 DNA sequences in human colorectal cancer
    Patent number: 8642271
    Abstract: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: February 4, 2014
    Assignees: Case Western Reserve University, Board of Regents, The University of Texas System
    Inventors: Sanford D. Markowitz, Helen Moinova, Lois Myeroff, Jean-Pierre Issa, Osamu Maeda
  • ABERRANT METHYLATION OF C6Orf150 DNA SEQUENCES IN HUMAN COLORECTAL CANCER
    Publication number: 20110165567
    Abstract: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.
    Type: Application
    Filed: August 27, 2010
    Publication date: July 7, 2011
    Inventors: Sanford D. Markowitz, Helen Moinova, Lois Myeroff, Jean-Pierre Issa, Osamu Maeda