Patents by Inventor Helen Rachel Bignell

Helen Rachel Bignell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ANALYZING NUCLEIC ACIDS
    Publication number: 20240076720
    Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.
    Type: Application
    Filed: February 9, 2023
    Publication date: March 7, 2024
    Inventors: Shankar BALASUBRAMANIAN, Jens FULLGRABE, Walraj Singh GOSAL, Joanna Dawn HOLBROOK, Sidong LIU, David MORLEY, Oliver NENTWICH, Tobias OST, Michael STEWARD, Albert VILELLA, Nicolas James WALKER, Shirong YU, Helen Rachel BIGNELL, Rita Santo SAN-BENTO
  • Methods for analyzing nucleic acids
    Patent number: 11608518
    Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: March 21, 2023
    Assignee: Cambridge Epigenetix Limited
    Inventors: Shankar Balasubramanian, Jens Fullgrabe, Walraj Singh Gosal, Joanna Dawn Holbrook, Sidong Liu, David Morley, Oliver Nentwich, Tobias Ost, Michael Steward, Albert Vilella, Nicolas James Walker, Shirong Yu, Helen Rachel Bignell, Rita Santo San-Bento
  • COMPOSITIONS AND METHODS FOR NUCLEIC ACID ANALYSIS
    Publication number: 20220298551
    Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.
    Type: Application
    Filed: March 21, 2022
    Publication date: September 22, 2022
    Inventors: Shankar BALASUBRAMANIAN, Jens FULLGRABE, Walraj Singh GOSAL, Joanna Dawn HOLBROOK, Sidong LIU, David MORLEY, Oliver NENTWICH, Tobias OST, Michael STEWARD, Albert VILELLA, Nicolas James WALKER, Shirong YU, Helen Rachel BIGNELL, Rita Santo SAN-BENTO
  • METHODS FOR ANALYZING NUCLEIC ACIDS
    Publication number: 20220290215
    Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.
    Type: Application
    Filed: March 21, 2022
    Publication date: September 15, 2022
    Inventors: Shankar BALASUBRAMANIAN, Jens FULLGRABE, Walraj Singh GOSAL, Joanna Dawn HOLBROOK, Sidong LIU, David MORLEY, Oliver NENTWICH, Tobias OST, Michael STEWARD, Albert VILELLA, Nicolas James WALKER, Shirong YU, Helen Rachel BIGNELL, Rita Santo SAN-BENTO
  • End modification to prevent over-representation of fragments
    Patent number: 10006081
    Abstract: The invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides and also the use of the 5? and 3? modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from when the 5? and 3? modified library is generated is greatly reduced or prevented.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 26, 2018
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Roberto Rigatti, Niall Anthony Gormley, Helen Rachel Bignell
  • Method of library preparation avoiding the formation of adaptor dimers
    Patent number: 9328378
    Abstract: The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends which is substantially free of adaptor-dimers.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: May 3, 2016
    Assignee: Illumina Cambridge Limited
    Inventors: David James Earnshaw, Niall Anthony Gormley, Helen Rachel Bignell, Melanie Anne Smith
  • END MODIFICATION TO PREVENT OVER-REPRESENTATION OF FRAGMENTS
    Publication number: 20150197789
    Abstract: The invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides and also the use of the 5? and 3? modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5? and 3? modified library is generated is greatly reduced or prevented.
    Type: Application
    Filed: March 24, 2015
    Publication date: July 16, 2015
    Applicant: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Roberto Rigatti, Niall Anthony Gormley, Helen Rachel Bignell
  • End modification to prevent over-representation of fragments
    Patent number: 9012184
    Abstract: The invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides and also the use of the 5? and 3? modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from when the 5? and 3? modified library is generated is greatly reduced or prevented.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: April 21, 2015
    Assignee: Illumina Cambridge Limited
    Inventors: Roberto Rigatti, Niall Anthony Gormley, Helen Rachel Bignell
  • METHOD OF LIBRARY PREPARATION AVOIDING THE FORMATION OF ADAPTOR DIMERS
    Publication number: 20100167954
    Abstract: The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends which is substantially free of adaptor-dimers.
    Type: Application
    Filed: July 30, 2007
    Publication date: July 1, 2010
    Applicant: SOLEXA LIMITED
    Inventors: David James Earnshaw, Niall Anthony Gormley, Helen Rachel Bignell, Melanie Anne Smith
  • End Modification to Prevent Over-Representation of Fragments
    Publication number: 20090176662
    Abstract: The invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides and also the use of the 5? and 3? modified library of templates in methods of solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a 5? and 3? modified library of template polynucleotides which have common sequences at their 5? ends and at their 3? ends, wherein over-representation of “end” sequences of the primary polynucleotide molecules from whence the 5? and 3? modified library is generated is greatly reduced or prevented.
    Type: Application
    Filed: February 7, 2007
    Publication date: July 9, 2009
    Inventors: Roberto Rigatti, Niall Anthony Gormley, Helen Rachel Bignell