Patents by Inventor Helen S. M. Lu
Helen S. M. Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150290961Abstract: The invention pertains to a printing form and a process for preparing the printing form from a solvent-free curable composition that includes, in prescribed relative amounts, an epoxy novolac resin; a bisphenol-A epoxy resin or a bisphenol-F epoxy resin; a monofunctional reactive diluent; a multifunctional o reactive diluent; and a stoichiometric amount of an amine curing agent. The ratio of the epoxy novolac resin to the bisphenol epoxy resin is 1:3 to 3:1 by weight. The process includes applying the curable composition to a supporting substrate to form a layer, curing the layer at one or more temperatures in a temperature range, and engraving to form at least one cell in the cured layer. The process prepares printing forms, particularly gravure printing forms, having a cured resin composition layer that is engravable, resistant to solvent inks and to mechanical wear, and capable of printing gravure-quality images.Type: ApplicationFiled: June 25, 2015Publication date: October 15, 2015Inventors: MARK E. WAGMAN, HELEN S.M. LU
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Patent number: 9096759Abstract: The invention pertains to a printing form and a process for preparing the printing form from a solvent-free curable composition that includes, in prescribed relative amounts, an epoxy novolac resin; a bisphenol-A epoxy resin or a bisphenol-F epoxy resin; a monofunctional reactive diluent; a multifunctional reactive diluent; and a stoichiometric amount of an amine curing agent. The ratio of the epoxy novolac resin to the bisphenol epoxy resin is 1:3 to 3:1 by weight. The process includes applying the curable composition to a supporting substrate to form a layer, curing the layer at one or more temperatures in a temperature range, and engraving to form at least one cell in the cured layer. The process prepares printing forms, particularly gravure printing forms, having a cured resin composition layer that is engravable, resistant to solvent inks and to mechanical wear, and capable of printing gravure-quality images.Type: GrantFiled: December 18, 2012Date of Patent: August 4, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Mark E Wagman, Helen S M Lu
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Patent number: 9044529Abstract: A hydrogel tissue adhesive formed by reacting an aminated polysaccharide with a water-dispersible, aldehyde-functionalized multi-arm polyether is described. The hydrogel tissue adhesive may be useful as a general tissue adhesive and sealant for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions. Additionally, due to the presence of the aminated polysaccharide, the hydrogel tissue adhesive may also promote wound healing and blood coagulation, and provide antimicrobial properties.Type: GrantFiled: August 31, 2009Date of Patent: June 2, 2015Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven Willis Shuey
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Publication number: 20150105346Abstract: A tissue adhesive formed by reacting an aminodextran containing primary amine groups with an oxidized dextran containing aldehyde groups is described. The dextran-based polymer tissue adhesive is particularly useful in medical applications where low swell and slow degradation are needed, for example sealing the dura, ophthalmic procedures, tissue repair, antiadhesive applications, drug delivery, and as a plug to seal a fistula or the punctum.Type: ApplicationFiled: August 21, 2014Publication date: April 16, 2015Applicant: Actamax Surgical Materials, LLCInventor: Helen S.M Lu
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Patent number: 8859705Abstract: A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.Type: GrantFiled: November 19, 2012Date of Patent: October 14, 2014Assignee: Actamax Surgical Materials LLCInventors: Helen S. M. Lu, Cara L. Blankenbicker
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Patent number: 8846095Abstract: A tissue adhesive formed by reacting an aminodextran containing primary amine groups with an oxidized dextran containing aldehyde groups is described. The dextran-based polymer tissue adhesive is particularly useful in medical applications where low swell and slow degradation are needed, for example sealing the dura, ophthalmic procedures, tissue repair, antiadhesive applications, drug delivery, and as a plug to seal a fistula or the punctum.Type: GrantFiled: November 14, 2008Date of Patent: September 30, 2014Assignee: Actamax Surgical Materials, LLCInventor: Helen S. M. Lu
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Publication number: 20140251168Abstract: The invention pertains to a printing form and a process for preparing the printing form from a curable composition that includes an epoxy resin, less than a stoichiometric amount of at least one amine curing agent, and optionally a catalytic curing agent and/or a latent curing agent. The process includes applying the curable composition to a supporting substrate to form a layer, partially curing the layer at a first temperature, engraving the partially cured layer, and then completing the curing by heating at a second temperature greater than the first temperature. The less than stoichiometric amount of the amine curing agent guarantees that after the first curing step, epoxy functionalities in the curable composition will be available for second curing step. The optional catalytic curing agent or latent curing agent promotes completion of the cure at higher temperature.Type: ApplicationFiled: March 5, 2014Publication date: September 11, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Helen S. M. LU, Mark E. WAGMAN
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Patent number: 8796242Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.Type: GrantFiled: March 12, 2013Date of Patent: August 5, 2014Assignee: Actamax Surgical Materials, LLCInventors: Helen S.M. Lu, Steven W. Shuey
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Patent number: 8785013Abstract: Compositions containing modified fullerenes and their use, for example, as films for membranes in electrode assemblies for electrochemical cells and fuel cells such as fuel cells are described.Type: GrantFiled: August 17, 2005Date of Patent: July 22, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Paul J. Krusic, Helen S. M. Lu, Zhen-Yu Yang
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Patent number: 8778326Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.Type: GrantFiled: June 30, 2010Date of Patent: July 15, 2014Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven W. Shuey
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Publication number: 20140142063Abstract: A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.Type: ApplicationFiled: November 19, 2012Publication date: May 22, 2014Applicant: Actamax Surgical Materials, LLCInventors: Helen S.M. Lu, Cara L. Blankenbicker
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Patent number: 8580950Abstract: Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: GrantFiled: December 21, 2010Date of Patent: November 12, 2013Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven W. Shuey
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Patent number: 8580951Abstract: Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: GrantFiled: July 1, 2010Date of Patent: November 12, 2013Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven W. Shuey
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Patent number: 8551136Abstract: A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.Type: GrantFiled: July 6, 2009Date of Patent: October 8, 2013Assignee: Actamax Surgical Materials, LLCInventor: Helen S. M. Lu
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Publication number: 20130255538Abstract: A low swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring low swell and slow degradation, for example, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; and as a plug to seal a fistula or the punctum. The low swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.Type: ApplicationFiled: March 12, 2013Publication date: October 3, 2013Inventor: Helen S.M. Lu
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Publication number: 20130261080Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.Type: ApplicationFiled: March 12, 2013Publication date: October 3, 2013Applicant: Actamax Surgical Materials LLCInventors: Helen S.M. Lu, Steven W. Shuey
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Patent number: 8426492Abstract: A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.Type: GrantFiled: November 14, 2008Date of Patent: April 23, 2013Assignee: Actamax Surgical Materials, LLCInventor: Helen S. M. Lu
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Publication number: 20120285930Abstract: The invention pertains to a printing form and a process for preparing the printing form from a curable composition that includes an epoxy novolac resin having an epoxide equivalent weight of 156 to 300 g/equivalent, and an amine curing agent selected from primary amines and secondary amines, the agent having an amine equivalent weight of less than or equal to 60 g/equivalent. The process includes applying the curable composition to a supporting substrate to form a layer, curing the layer at one or more temperatures in a temperature range, and engraving to form at least one cell in the cured layer. The process prepares printing forms, particularly gravure printing forms, having a cured resin composition layer that is engravable, resistant to solvent inks and to mechanical wear, and capable of printing gravure-quality images.Type: ApplicationFiled: May 11, 2012Publication date: November 15, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Douglas J. Adelman, Cara L. Blankenbicker, Andrew P. Davis, Barbara B. Fones, Helen S. M. Lu, Mark E. Wagman
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Publication number: 20120148523Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.Type: ApplicationFiled: June 30, 2010Publication date: June 14, 2012Applicant: Actamax Surgical Materials LLCInventors: Helen S.M. Lu, Steven W. Shuey
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Publication number: 20120142787Abstract: Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: ApplicationFiled: December 21, 2010Publication date: June 7, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Helen S. M. LU, STEVEN W. SHUEY