Patents by Inventor Helen Sarah Niblock

Helen Sarah Niblock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Morpholino substituted urea derivatives as mTOR inhibitors
    Patent number: 9249129
    Abstract: The invention relates to compounds of formula (I) wherein X1, X2, R1 to R4, m, and n have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 2, 2016
    Assignee: CELLZOME LIMITED
    Inventors: Jessica Taylor, Daniel Paul Hardy, Rosemary Lynch, Helen Sarah Niblock, Andrew David Cansfield
  • PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS
    Publication number: 20140296234
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Rosemary LYNCH, Andrew David CANSFIELD, Helen Sarah NIBLOCK, Daniel HARDY, Jane Elizabeth SCANLON, Rita ADREGO, Nigel RAMSDEN
  • Pyrimidine derivatives as mTOR inhibitors
    Patent number: 8785457
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. The compounds of formula (I) are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: July 22, 2014
    Assignee: Cellzome Limited
    Inventors: Rosemary Lynch, Andrew David Cansfield, Helen Sarah Niblock, Daniel Hardy, Jane Elizabeth Scanlon, Rita Adrego, Nigel Ramsden
  • MORPHOLINO SUBSTITUTED UREA DERIVATIVES AS MTOR INHIBITORS
    Publication number: 20130196982
    Abstract: The invention relates to compounds of formula (I) wherein X1, X2, R1 to R4, m, n have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: March 4, 2011
    Publication date: August 1, 2013
    Inventors: Rosemary Lynch, Andrew David Cansfield, Helen Sarah Niblock, Daniel Paul Hardy, Jessica Taylor
  • PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
    Publication number: 20120065202
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: March 12, 2010
    Publication date: March 15, 2012
    Inventors: Rosemary Lynch, Andrew David Cansfield, Helen Sarah Niblock, Daniel Hardy, Jane Elizabeth Scanlon, Rita Adrego, Nigel Ramsden