Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

Abstract: Systems and methods herein are for hose management in a computing module. A rotatable support structure includes a moveable inset structure and is to support rotation movement of cooling hoses that are to cool underlying devices in the computing module, where the rotation movement is about an axis of the computing module to allow the cooling hoses to be moved away from the underlying devices of the computing module and where the movable inset structure is movable within the rotatable support structure to receive tension on the cooling hoses from being coupled to a manifold of the computing module.

Abstract: The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof. The invention further relates to the compounds of formula (I) for use in methods for treating a bacterial infection, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic. The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological assays thereof. An exemplary compound is e.g.

Abstract: Systems and methods are provided for providing an interface for accessing a data analysis workbook through which data can be accessed and manipulated using a plurality of programming languages and application programming interfaces (APIs). Input data on which one or more data transformations are to be performed within the data analysis workbook can be accessed, wherein the input data corresponds to a first object representation of a dataset, and wherein the one or more data transformations require the dataset to be a different, second object representation of the dataset. The second object representation of the dataset can be extracted from the first object representation of the dataset through a first language delegate that manages data associated with the first object representation. The one or more data transformations can be applied to the extracted second object representation of the dataset through a different, second language delegate that manages data associated with the second object representation.

Abstract: A system for enabling granular access control over ontology data and related methods are disclosed. The system is programmed to receive data source updates from data sources having respective sets of permissions for access control, transform the data source updates to changes to an ontology, and control access to the ontology based on the sets of permissions. The system is further programmed to receive a specification of one or more rules referencing attributes of user accounts or properties of ontology entities and corresponding one or more lists of permissions. The system is programmed to then enforce a security policy based on the specification to further control access to the ontology.

Abstract: A system for resolving conflicts between data source updates and user edits to an ontology before applying the resulting changes to the ontology and related methods are disclosed. The system is programmed to receive data source updates from data sources and transform the data source updates to updates to ontology data. The system is also programmed to receive edits to ontology data from user accounts. The system is programmed to review these updates or edits to the ontology and resolve conflicts according to a predetermined strategy, such as prioritizing a user edit over a data source update. The resulting changes are incorporated to one or more databases where representations of the ontology data are stored.

Abstract: A system for indexing changes to an ontology into multiple databases and related methods are disclosed. The system is programmed to receive original data from data sources, transform the original data to ontology data, represent the ontology data in multiple forms respectively in the multiple databases, and process requests to access the ontology data from user accounts using the multiple databases. The system is programmed to subsequently merge changes to the ontology data based on updates from the data sources and edits from user accounts, create index data for the merged changes, and transmit the index data to the multiple databases.

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

Abstract: Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

Abstract: Systems and methods for generating ligand compound structures are provided. A trained computational framework can utilize an initial core ligand compound structure to generate a ligand compound structure by iteratively adding atomic structures. At each iterative step, the computational framework can select a location for adding an atomic structure and can further select which atomic structure is to be added the selected location.

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

Abstract: Systems and methods are provided for providing an interface for accessing a data analysis workbook through which data can be accessed and manipulated using a plurality of programming languages and application programming interfaces (APIs). Input data on which one or more data transformations are to be performed within the data analysis workbook can be accessed, wherein the input data corresponds to a first object representation of a dataset, and wherein the one or more data transformations require the dataset to be a different, second object representation of the dataset. The second object representation of the dataset can be extracted from the first object representation of the dataset through a first language delegate that manages data associated with the first object representation. The one or more data transformations can be applied to the extracted second object representation of the dataset through a different, second language delegate that manages data associated with the second object representation.

Abstract: Systems and methods are provided for providing an interface for accessing a data analysis workbook through which data can be accessed and manipulated using a plurality of programming languages and application programming interfaces (APIs). Input data on which one or more data transformations are to be performed within the data analysis workbook can be accessed, wherein the input data corresponds to a first object representation of a dataset, and wherein the one or more data transformations require the dataset to be a different, second object representation of the dataset. The second object representation of the dataset can be extracted from the first object representation of the dataset through a first language delegate that manages data associated with the first object representation. The one or more data transformations can be applied to the extracted second object representation of the dataset through a different, second language delegate that manages data associated with the second object representation.

Abstract: Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.

Abstract: Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.

Abstract: Systems and methods are provided for providing an interface for accessing a data analysis workbook through which data can be accessed and manipulated using a plurality of programming languages and application programming interfaces (APIs). Input data on which one or more data transformations are to be performed within the data analysis workbook can be accessed, wherein the input data corresponds to a first object representation of a dataset, and wherein the one or more data transformations require the dataset to be a different, second object representation of the dataset. The second object representation of the dataset can be extracted from the first object representation of the dataset through a first language delegate that manages data associated with the first object representation. The one or more data transformations can be applied to the extracted second object representation of the dataset through a different, second language delegate that manages data associated with the second object representation.

Abstract: Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.

Abstract: Techniques related to searches of highly structured data are described. A body of data may be represented by an object-centric data model. For a search of the body of data, an indication of a particular search template to use may be received. The particular search template may specify one or more hierarchical object types that are within a scope of the search. The one or more hierarchical object types may be defined in the object-centric data model. The particular search template may specify at least one search field. A user interface may be generated based on the particular search template. The user interface may include the at least one search field.

Abstract: Techniques related to searches of highly structured data are described. A body of data may be represented by an object-centric data model. For a search of the body of data, an indication of a particular search template to use may be received. The particular search template may specify one or more hierarchical object types that are within a scope of the search. The one or more hierarchical object types may be defined in the object-centric data model. The particular search template may specify at least one search field. A user interface may be generated based on the particular search template. The user interface may include the at least one search field.