Patents by Inventor Helena SAFAVI-HEMAMI

Helena SAFAVI-HEMAMI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Mini-Insulin With Extended C-Terminal A Chain
    Publication number: 20220389073
    Abstract: Disclosed are peptides comprising an insulin A chain peptide and an insulin B chain peptide, wherein the B chain peptide comprises a substitution at amino acid 10 and amino acid 20. Disclosed are methods of increasing insulin receptor activation in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of lowering the blood sugar in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of treating type 1 diabetes in a subject comprising administering a therapeutically effective amount of a disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 8, 2022
    Inventors: Danny Hung-Chieh Chou, Helena Safavi-Hemami
  • INSULIN ANALOGS
    Publication number: 20220340636
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: January 4, 2022
    Publication date: October 27, 2022
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Baldomero M. OLIVERA
  • Insulin analogs
    Patent number: 11248034
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: February 15, 2022
    Assignees: University of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical Research
    Inventors: John Gerbrandt Tasman Menting, Brian Smith, Danny Hung-Chieh Chou, Helena Safavi-Hemami, Michael Colin Lawrence, Baldomero M. Olivera
  • INSULIN ANALOGS
    Publication number: 20190241640
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 8, 2019
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Olivera M. BALDOMERO