Patents by Inventor Helene Derand
Helene Derand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7833486Abstract: A microfluidic device that comprises one or a plurality of microchannel structures each of which comprises a microconduit for transport and/or processing of liquid, the inner surface of which comprises a hydrophilic liquid contact surface area (surface area 1) that is delineated in at least one direction by a boundary to a hydrophobic surface area (surface area 2). The characteristic feature is that surface area 2 comprises a rough part that stretches along the boundary.Type: GrantFiled: November 21, 2005Date of Patent: November 16, 2010Assignee: Gyros Patent ABInventors: Matthew Fielden, Therese Sennefors, Helene Dérand
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Patent number: 7553393Abstract: A method for covering a set of open microchannel structures which are fabricated on a planar surface made of plastics and which comprise two or more part areas that have different surface characteristics. The method comprises the steps of: a) providing the surface comprising the set of microchannel structures; b) providing a lid-forming sheet having on one side an even layer of a thermoglue; c) applying the side of the sheet having the thermoglue against the surface carrying the microchannel structure; d) heating the assembly created in step (c) to selectively liquefy the hot-melt adhesive while at the same time pressing the sheet material and the planar surface of the substrate together; e) permitting the resulting laminate-covered microchannel structure to cool.Type: GrantFiled: January 22, 2001Date of Patent: June 30, 2009Assignee: Gyros ABInventors: Helene Derand, Anders Larsson
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Patent number: 7429354Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances.Type: GrantFiled: March 19, 2002Date of Patent: September 30, 2008Assignee: Gyros Patent ABInventors: Per Andersson, Gunnar Ekstrand, Ulrike Selditz, Sussanne Wallenborg, Helene Derand, Gunnar Thorsen, Ebru Togan-Tekin
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Patent number: 7282237Abstract: A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P?) carrying nucleophilic groups X?. The method is characterized in (a) ethoxylating a plurality of said X? thereby transforming them to groups comprising —(CH2CH2O)nH, or (b) (i) ethoxylating a polymer (P?) carrying nucleophilic groups X? thereby transforming P? to a polyhydroxy polymer (P??) carrying a plurality of —(CH2CH2O)nH groups, whereafter (ii) P?? is attached to the base matrix. n is an integer ?1. A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity >5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug.Type: GrantFiled: September 12, 2005Date of Patent: October 16, 2007Assignee: GE Healthcare Bio-Sciences ABInventors: Helene Derand, Rose Nasman, legal representative, Harry Nasman, legal representative, Jan Nasman, deceased
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Patent number: 7238255Abstract: A method for increasing the yield of functional microchannel structures per microfluidic device in the manufacturing of microfluidic devices each of which comprises a plurality of enclosed microchannel structures, said manufacturing comprising the manufacture of a microfluidic device which comprises enclosed microchannel structures by joining a substrate surface I of a first generally planar plastic substrate I to a substrate surface II of a second generally planar substrate II via a bonding material.Type: GrantFiled: December 27, 2002Date of Patent: July 3, 2007Assignee: Gyros Patent ABInventors: Helene Derand, Lars Lundbladh, Olle Larsson, Lars Rosengren
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Publication number: 20070054270Abstract: A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a dry state together with a bed-preserving agent comprising one or more compounds having bed-preserving activity.Type: ApplicationFiled: March 23, 2004Publication date: March 8, 2007Applicant: GYROS PATENT ABInventors: Mats Inganas, Susanna Lindman, Helene Derand
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Publication number: 20060278287Abstract: A microfluidic device that comprises one or a plurality of microchannel structures each of which comprises a microconduit for transport and/or processing of liquid, the inner surface of which comprises a hydrophilic liquid contact surface area (surface area 1) that is delineated in at least one direction by a boundary to a hydrophobic surface area (surface area 2). The characteristic feature is that surface area 2 comprises a rough part that stretches along the boundary.Type: ApplicationFiled: November 21, 2005Publication date: December 14, 2006Inventors: Matthew Fielden, Therese Sennerfors, Helene Derand
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Patent number: 7148476Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.Type: GrantFiled: June 15, 2004Date of Patent: December 12, 2006Assignee: Gyros Patent ABInventors: Per Andersson, Helene Derand, Magnus Gustafsson, Anders Palm, Sussanne Wallenborg
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Patent number: 7104517Abstract: The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs (34) of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way (32) for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (34). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.Type: GrantFiled: June 30, 2000Date of Patent: September 12, 2006Assignee: Gyros Patent ABInventors: Helene Derand, Per Andersson, Anders Larsson
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Publication number: 20060020087Abstract: A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P?) carrying nucleophilic groups X?. The method is characterized in (a) ethoxylating a plurality of said X? thereby transforming them to groups comprising —(CH2CH2O)nH, or (b) (i) ethoxylating a polymer (P?) carrying nucleophilic groups X? thereby transforming P? to a polyhydroxy polymer (P??) carrying a plurality of —(CH2CH2O)nH groups, whereafter (ii) P?? is attached to the base matrix. n is an integer?1. A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity>5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug.Type: ApplicationFiled: September 12, 2005Publication date: January 26, 2006Inventors: Helene Derand, Jan Nasman, Rose Nasman, Harry Nasman
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Publication number: 20060002825Abstract: A microfluidic disc having one or more enclosed microchannel structures, and the microchannel structures are intended to be used for transport of transporting liquids. The device is characterized in that at least a part of the inner walls of each of one or more microchannel structures are treated with a gas plasma having one or more organic precursor compounds.Type: ApplicationFiled: August 26, 2005Publication date: January 5, 2006Inventors: Helene Derand, Frida Jernstrom
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Publication number: 20050279925Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.Type: ApplicationFiled: June 15, 2004Publication date: December 22, 2005Inventors: Per Andersson, Helene Derand, Magnus Gustafsson, Anders Palm, Susanne Wallenborg
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Patent number: 6967101Abstract: A method for rendering a surface covered by a plastic material more hydrophilic by treatment with a gas plasma non-polymerizable gas. The method is characterized in that the intensity of the plasma is selected so that the surface becomes permanently more hydrophilic. Also disclosed is a naked plasma treated surface of plastic having an immediate water contact angle of ?30°, said water contact angle is changed ±20 and/or less than 5% upon washing with an ethanol/water mixture (70% w/w).Type: GrantFiled: March 24, 2000Date of Patent: November 22, 2005Assignee: Gyros ABInventors: Anders Larsson, Anette Ocklind, Helene Derand
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Patent number: 6955738Abstract: A microfluidic disc having one or more enclosed microchannel structures, and the microchannel structures are intended to be used for transport of transporting liquids. The device is characterized in that at least a part of the inner walls of each of one or more microchannel structures are treated with a gas plasma having one or more organic precursor compounds.Type: GrantFiled: April 9, 2003Date of Patent: October 18, 2005Assignee: Gyros ABInventors: Helene Derand, Frida Jernstrom
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Publication number: 20050214442Abstract: A microfabricated device having a liquid transportation system which is formed in/on a polymer material (plastics) that is a polymerised aliphatic monomer containing unsaturation.Type: ApplicationFiled: December 20, 2004Publication date: September 29, 2005Inventors: Anders Larsson, Helene Derand
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Publication number: 20050186685Abstract: A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.Type: ApplicationFiled: January 20, 2005Publication date: August 25, 2005Inventors: Rickard Kange, Mats Inganas, Magnus Gustafsson, Johan Engstrom, Bo Ek, Helene Derand, Ann-Kristin Honerud
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Publication number: 20050153431Abstract: A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).Type: ApplicationFiled: December 13, 2004Publication date: July 14, 2005Inventors: Per Andersson, Gunnar Ekstrand, Helene Derand
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Publication number: 20050042770Abstract: A method for processing two or more liquid aliquots in a microchannnel structure of a microfluidic device. The microchannel structure comprises a hydrophilic microconduit with a fluidic function and a local non-wettable surface associated with the fluidic function/microconduit. Other aspects comprise a method for producing the fluidic function, which comprises introducing non-wettability on a local surface area S that is associated with the microconduit.Type: ApplicationFiled: May 19, 2004Publication date: February 24, 2005Inventors: Helene Derand, Matthew Fielden, Cecillia Hellermark, Rickard Kange, Therese Sennefors
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Publication number: 20040239234Abstract: A dual-side field-emission display has one cathode plate and two anode plates. The cathode plate has two opposite surfaces, and each surface has a cathode conductive layer and an electron emission layer formed thereon. The anode plates are disposed at two opposing sides of the cathode plate. Each of the anode plates has an anode conductive layer and a phosphor layer.Type: ApplicationFiled: June 16, 2004Publication date: December 2, 2004Inventors: Per Andersson, Helene Derand, Magnus Gustafsson, Anders Palm, Sussanne Wallenborg
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Patent number: 6812457Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.Type: GrantFiled: July 17, 2003Date of Patent: November 2, 2004Assignee: Gyros ABInventors: Per Andersson, Helene Derand, Magnus Gustafsson, Anders Palm, Susanne Wallenborg