Patents by Inventor Helene F. Rosenberg

Helene F. Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNase a peptides, fragments and uses thereof
    Patent number: 8748572
    Abstract: The present invention features isolated polypeptides that have bactericidal and angiogenic activities. The invention features isolated polypeptides comprising amino acid sequences of RNase A ribonucleases, fragments and variants thereof, pharmaceutical compositions, and methods for treatment of a subject.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: June 10, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Takeaki Nitto, Kimberly D. Dyer, Meggan Czapiga, Helene F. Rosenberg, Steven J. Siegel
  • RNASE A PEPTIDES, FRAGMENTS AND USES THEREOF
    Publication number: 20100305025
    Abstract: The present invention features isolated polypeptides that have bactericidal and angiogenic activities. The invention features isolated polypeptides comprising amino acid sequences of RNase A ribonucleases, fragments and variants thereof, pharmaceutical compositions, and methods for treatment of a subject.
    Type: Application
    Filed: August 24, 2007
    Publication date: December 2, 2010
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Takeaki Nitto, Kimberly D. Dyer, Meggan Czapiga, Helene F. Rosenberg, Steven J. Siegel
  • Methods for inactivating enveloped RNA virus particles and compositions for use therewith
    Patent number: 6426070
    Abstract: A method for inactivating a virion of an enveloped RNA virus comprising contacting the virion with an eosinophil-derived ribonuclease, such as eosinophil-derived neurotoxin (EDN) or eosinophil cationic protein (ECP). The invention also provides methods for treating a subject infected by an enveloped RNA virus and for preventing infection by an enveloped RNA virus comprising administering an effective amount of an eosinophil-derived ribonuclease, such as EDN or ECP. The invention also provides a composition comprising an effective amount of an eosinophil-derived ribonuclease and an acceptable carrier.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: July 30, 2002
    Assignee: The United States as represented by the Department of Health and Human Services
    Inventors: Helene F. Rosenberg, Joseph B. Domachowske
  • Recombinant gene encoding human Charcot-Leyden crystal protein
    Patent number: 5242807
    Abstract: A recombinant DNA molecule consisting of segments of DNA from different genomes which have been joined end-to-end outside of living cells, and the progeny of such a recombinant DNA molecule, which recombinant DNA molecule (1) has the capacity to infect a host cell and to be maintained therein, and (2) comprises a DNA coding sequence selected from the group consisting of:(a) the CLCP-encoding sequence shown in FIG. 1,(b) a DNA sequence which hybridizes to the CLCP-encoding sequence shown in FIG. 1, and which encodes a polypeptide which (i) cross-reacts with an antibody to CLCP or to denatured CLCP, (ii) exhibits lysophospholipase activity, and (iii) forms dipyramidal crystals under conditions permitting CLC formation; and(c) a DNA sequence encoding a polypeptide encoded by any of the foregoing DNA sequences.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: September 7, 1993
    Assignee: Beth Israel Hospital Association
    Inventors: Steven J. Ackerman, Helene F. Rosenberg, Daniel G. Tenen