Patents by Inventor Helge Grosshans

Helge Grosshans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATING XRN1
    Publication number: 20130034543
    Abstract: The present invention relates to a method for modulating miRNA, said method being characterized in that a modulator of XRN1 is used. Also provided are uses of said method for therapeutical purposes, reagents therefore, as well as screening methods.
    Type: Application
    Filed: April 18, 2011
    Publication date: February 7, 2013
    Applicant: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Resear
    Inventors: Saibal Chatterjee, Helge Grosshans
  • MODULATING XRN2
    Publication number: 20110300155
    Abstract: The present invention relates to a method for modulating miRNA, said method being characterized in that a modulator of XRN2 is used. Also provided are uses of said method for therapeutical purposes, reagents therefore, as well as screening methods.
    Type: Application
    Filed: December 3, 2009
    Publication date: December 8, 2011
    Applicant: NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG, F RIEDRICH MIESCHER INSTITUTE FOR BIOMWDICAL RESEAR
    Inventors: Saibal Chatterjee, Helge Grosshans
  • REGULATION OF ONCOGENES BY MICRORNAS
    Publication number: 20110054006
    Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.
    Type: Application
    Filed: April 26, 2010
    Publication date: March 3, 2011
    Applicant: Yale University
    Inventors: Frank J. Slack, Steven M. Johnson, Helge Grosshans, Joanne Barnes Weidhaas
  • Regulation of oncogenes by microRNAs
    Patent number: 7893034
    Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: February 22, 2011
    Assignee: Yale University
    Inventors: Frank J. Slack, Steven M. Johnson, Helge Grosshans
  • Regulation of oncogenes by microRNAs
    Patent number: 7741306
    Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA ,or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: June 22, 2010
    Assignee: Yale University
    Inventors: Frank J. Slack, Steven M. Johnson, Helge Grosshans, Joanne Barnes Weidhaas
  • REGULATION OF ONCOGENES BY MICRORNAS
    Publication number: 20080119436
    Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions are administered to a subject prior to administration of a cytotoxic therapy in an amount effective to sensitize cells or tissues to be treated to the effects of the cytotoxic therapy.
    Type: Application
    Filed: October 22, 2007
    Publication date: May 22, 2008
    Inventors: Frank J. Slack, Steven M. Johnson, Helge Grosshans
  • Regulation of oncogenes by microRNAs
    Publication number: 20060189557
    Abstract: Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.
    Type: Application
    Filed: September 2, 2005
    Publication date: August 24, 2006
    Inventors: Frank Slack, Steven Johnson, Helge Grosshans