Patents by Inventor Helge Tolleshaug

Helge Tolleshaug has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Contrast agents
    Publication number: 20030170173
    Abstract: This invention relates to contrast agents and the use of these contrast agents for diagnosis of diseases in humans and animals based on mapping of metabolic activity. The contrast agents can be used to identify tissue or cells with metabolic activity or enzymatic activity deviating from the normal. A contrast agent substrate changes pharmacodynamic and/or pharmacokinetic properties upon a chemical modification from a contrast agent substrate to a contrast agent product in a specific enzymatic transformation, thereby detecting areas of disease upon a deviation in the enzyme activity from the normal.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 11, 2003
    Inventors: Jo Klaveness, Helge Tolleshaug, Alan Cuthbertson, Mari Ann Kulseth
  • Contrast agents
    Patent number: 6610269
    Abstract: The invention provides a composition of matter of the formula (I): V—L—R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterized in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: August 26, 2003
    Assignee: Amersham Health AS
    Inventors: Jo Klaveness, Anne Naevestad, Helge Tolleshaug
  • Diagnostic/therapeutic agents
    Publication number: 20020102217
    Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
    Type: Application
    Filed: August 10, 2001
    Publication date: August 1, 2002
    Applicant: Nycomed Imaging AS
    Inventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Naevestad, Dagfinn Lovhaug, Halldis Hellebust, Magne Solbakken
  • Diagnostic/therapeutic agents
    Publication number: 20020102215
    Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilized by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
    Type: Application
    Filed: January 22, 2001
    Publication date: August 1, 2002
    Applicant: NYCOMED IMAGING AS
    Inventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Anne Naevestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Lovhaug, Magne Solbakken
  • Targeted diagnostic/therapeutic agents having more than one different vectors
    Patent number: 6331289
    Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: December 18, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Alan Cuthbertson, Lars Hoff, Klaus Bryn, Halldis Hellebust, Magne Solbakken
  • Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
    Patent number: 6261537
    Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: July 17, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Anne Nævestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Løvhaug, Magne Solbakken