Patents by Inventor Helge Werner

Helge Werner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8613857
    Abstract: A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: December 24, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Harald Groeger, Claudia Rollmann, Helge Werner, Francoise-Christine Chamouleau, Dittmar Orzewski
  • Patent number: 8105806
    Abstract: The present invention relates to a process for preparing, in particular, enantiomerically enriched L-?-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are converted into the desired products using a whole-cell catalyst which comprises an amino acid dehydrogenase and a cofactor-regenerating enzyme.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: January 31, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Harald Groeger, Helge Werner, Josef Altenbuchner, Anne Menzel, Werner Hummel
  • Patent number: 7632665
    Abstract: The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: December 15, 2009
    Assignee: Evonik Degussa GmbH
    Inventors: Harald Gröger, Claudia Rollmann, Hendrik Hüsken, Helge Werner, Francoise Chamouleau, Chad Hagedorn, Karlheinz Drauz, Werner Hummel
  • Publication number: 20090087885
    Abstract: The present invention relates to a process for preparing, in particular, enantiomerically enriched L-?-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are converted into the desired products using a whole-cell catalyst which comprises an amino acid dehydrogenase and a cofactor-regenerating enzyme.
    Type: Application
    Filed: March 18, 2005
    Publication date: April 2, 2009
    Applicant: DEGUSSA AG
    Inventors: Harald Groeger, Helge Werner, Josef Altenbuchner, Anne Menzel, Werner Hummel
  • Publication number: 20080006579
    Abstract: A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product.
    Type: Application
    Filed: June 21, 2007
    Publication date: January 10, 2008
    Applicant: DEGUSSA GmbH
    Inventors: Harald Groeger, Claudia Rollmann, Helge Werner, Francoise-Christine Chamouleau, Dittmar Orzewski
  • Publication number: 20060216801
    Abstract: The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.
    Type: Application
    Filed: March 17, 2004
    Publication date: September 28, 2006
    Applicant: Degussa AG
    Inventors: Harald Groger, Claudia Rollmann, Hendrik Husken, Helge Werner, Francoise Chamouleau, Chad Hagedorn, Karlheinz Drauz, Werner Hummel
  • Patent number: 6987010
    Abstract: The present invention relates to processes for the preparation of enantiomerically enriched ?-amino acids. The invention also relates to advantageous esters of ?-amino acids of the general formula (I) and to the use thereof in the enzymatic preparation of enantiomerically enriched ?-amino acids.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: January 17, 2006
    Assignee: Degussa AG
    Inventors: Harald Gröger, Helge Werner
  • Publication number: 20050153401
    Abstract: A process is described for preparing optically active ?-atninocarboxylic acids from racemic N-acylated ?-aminocarboxylic acids by cnantiosclccthc hydrolysis of the N-acylated ?-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated ?-aminocarboxylic acid (I) exhibits Structure I in which R1, R2 are each selected, independently of one another, from H, halogen, alkiyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.
    Type: Application
    Filed: March 7, 2003
    Publication date: July 14, 2005
    Inventors: Harald Groger, Harald Trauthwein, Karlheinz Drauz, Stefan Buchholz, Christiane Sacherer, Helge Werner
  • Publication number: 20050142646
    Abstract: The present invention relates to processes for the preparation of enantiomerically enriched ?-amino acids. The invention also relates to advantageous esters of ?-amino acids of the general formula (I) and to the use thereof in the enzymatic preparation of enantiomerically enriched ?-amino acids.
    Type: Application
    Filed: February 8, 2005
    Publication date: June 30, 2005
    Inventors: Harald Groger, Helge Werner
  • Patent number: 6869781
    Abstract: The present invention relates to processes for the preparation of enantiomerically enriched ?-amino acids. The invention also relates to advantageous esters of ?-amino acids of the general formula (I) and to the use thereof in the enzymatic preparation of enantiomerically enriched ?-amino acids.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: March 22, 2005
    Assignee: Degussa AG
    Inventors: Harald Gröger, Helge Werner
  • Publication number: 20040029236
    Abstract: The present invention relates to processes for the preparation of enantiomerically enriched &bgr;-amino acids.
    Type: Application
    Filed: May 7, 2003
    Publication date: February 12, 2004
    Applicant: Degussa AG
    Inventors: Harald Groger, Helge Werner